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科研机构
上海药物研究所 [71]
内容类型
期刊论文 [69]
学位论文 [2]
发表日期
2022 [1]
2021 [3]
2020 [3]
2019 [1]
2018 [4]
2016 [3]
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Biochemist... [3]
Chemistry [3]
Pharmacolo... [3]
Endocrinol... [2]
Oncology [1]
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The discovery of a novel series of potential ERR alpha inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo
期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 125-134
作者:
Gao, Zhipei
;
Wang, Tianxiao
;
Li, Rui
;
Du, Yongli
;
Lv, Han
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/01/18
ERR alpha
TNBC
p-Nitrobenzenesulfonamide
inverse agonist
Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11
作者:
Li, Bo
;
Li, Heng
;
Zhu, Zhengdan
;
Xiang, Caigui
;
Xu, Zhijian
收藏
  |  
浏览/下载:99/0
  |  
提交时间:2021/11/04
Anti-inflammatory activity
TNF alpha
ER beta
IBD Arylisoquinolones
Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis
期刊论文
ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 页码: 14
作者:
Liu, Siyu
;
Mao, Hui
;
Qiao, Jin
;
Zhang, Xiaoning
;
Lu, Yangbin
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  |  
浏览/下载:73/0
  |  
提交时间:2021/11/04
Iridium
C-H activation
[3+2] annulation
Tetrasubstituted alkene
pyrrolo[1,2-a]indole
Molecular Dynamics Simulations Based on 1-Phenyl-4-Benzoyl-1-Hydro-Triazole ERR alpha Inverse Agonists
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 7, 页码: 14
作者:
Gao, Zhipei
;
Du, Yongli
;
Sheng, Xiehuang
;
Shen, Jingkang
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
ERRα
inverse agonists
1-phenyl-4-benzoyl-1-hydro-triazole
MD simulations
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases
期刊论文
MEDICINAL RESEARCH REVIEWS, 2020, 页码: 74
作者:
Panossian, Alexander G.
;
Efferth, Thomas
;
Shikov, Alexander N.
;
Pozharitskaya, Olga N.
;
Kuchta, Kenny
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  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
adaptogen
aging
ethnopharmacology
network pharmacology
stress
Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-alpha and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells
期刊论文
PHYTOMEDICINE, 2020, 卷号: 68, 页码: 12
作者:
Wu, Qing-Chang
;
Tang, Xi-Yang
;
Dai, Zi-Qin
;
Dai, Yi
;
Xiao, Hui-Hui
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Sweroside
Differentiation and mineralization
Membrane estrogen receptor-alpha
GPR30
P38 signaling pathway
MC3T3-E1 cells
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate
期刊论文
FASEB JOURNAL, 2020, 页码: 18
作者:
Hait, Nitai C.
;
Maiti, Aparna
;
Xu, Pan
;
Qi, Qianya
;
Kawaguchi, Tsutomu
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  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
hypoxia-inducible factors
sphingosine-1-phosphate
sphingosine kinase 2
triple-negative breast cancer
Designing of novel ERR gamma inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 10, 页码: 1661-1673
作者:
Li, Rui
;
Du, Yongli
;
Shen, Jingkang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
ERR gamma inverse agonist
Molecular docking
3D-QSAR
CoMFA
CoMSIA
A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 5, 页码: 5891-5899
作者:
Wei, Shunfeng
;
Chen, Wantao
;
Hu, Lihong
;
Pan, Jinsong
;
Wang, Xu
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
multidrug resistance
ATP-binding cassette subfamily B member 1
toxicity
pharmacokinetics
Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice
期刊论文
Phytotherapy research : PTR, 2018
作者:
Xu, Ying
;
Li, Xin
;
Chen, Ting
;
Qu, Ya-Kun
;
Zheng, Hong-Xia
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  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
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