Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases

doi:10.1002/med.21743

	Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases
	Panossian, Alexander G.1; Efferth, Thomas 2; Shikov, Alexander N.3; Pozharitskaya, Olga N.4; Kuchta, Kenny 5; Mukherjee, Pulok K.6; Banerjee, Subhadip 6; Heinrich, Michael 7; Wu, Wanying 8; Guo, De-an 8
刊名	MEDICINAL RESEARCH REVIEWS
	2020-10-25
页码	74
关键词	adaptogen aging ethnopharmacology network pharmacology stress
ISSN号	0198-6325
DOI	10.1002/med.21743
通讯作者	Panossian, Alexander G.(ap@phytomed.se)
英文摘要	Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress-induced and aging-related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine-immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose-effect response: at low doses they function as mild stress-mimetics, which activate the adaptive stress-response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging-related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress-induced and aging-related diseases.
WOS关键词	NF-KAPPA-B ; KOREAN RED GINSENG ; RHODIOLA-ROSEA L. ; ANDROGRAPHIS-PANICULATA EXTRACT ; ESTROGEN-RECEPTOR-ALPHA ; SOLID-PHASE EXTRACTION ; CENTRAL-NERVOUS-SYSTEM ; COMBINATION KAN-JANG ; ELEUTHEROCOCCUS-SENTICOSUS EXTRACT ; ISCHEMIA-REPERFUSION INJURY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000583172600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292517]
专题	中国科学院上海药物研究所
通讯作者	Panossian, Alexander G.
作者单位	1.Phytomed AB, Vaxtorp, Sweden 2.Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Mainz, Germany 3.St Petersburg State Chem Pharmaceut Univ, Dept Technol Dosage Forms, St Petersburg, Russia 4.Russian Acad Sci MMBI KSC RAS, Murmansk Marine Biol Inst, Dept Biotechnol, Kola Sci Ctr, Murmansk, Russia 5.Univ Med Ctr Gottingen, Dept Far Eastern Med, Clin Gastroenterol & Gastrointestinal Oncol, Gottingen, Germany 6.Jadavpur Univ, Sch Nat Prod Studies, Dept Pharmaceut Technol, Kolkata, India 7.Univ London, UCL Sch Pharm, Ctr Pharmacognosy & Phytotherapy, Res Cluster Biodivers & Med, London, England 8.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai, Peoples R China 9.Ludwig Maximilians Univ Munchen, Dept Pharm, Pharma Res Ctr, Munich, Germany
推荐引用方式 GB/T 7714	Panossian, Alexander G.,Efferth, Thomas,Shikov, Alexander N.,et al. Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases[J]. MEDICINAL RESEARCH REVIEWS,2020:74.
APA	Panossian, Alexander G..,Efferth, Thomas.,Shikov, Alexander N..,Pozharitskaya, Olga N..,Kuchta, Kenny.,...&Wagner, Hildebert.(2020).Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.MEDICINAL RESEARCH REVIEWS,74.
MLA	Panossian, Alexander G.,et al."Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases".MEDICINAL RESEARCH REVIEWS (2020):74.