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科研机构
上海药物研究所 [325]
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期刊论文 [320]
会议论文 [4]
学位论文 [1]
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2021 [43]
2020 [37]
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Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Chen, Cheng
;
Ren, Yong-mei
;
Zhu, Jian-zhong
;
Chen, Jia-li
;
Feng, Zhe-ling
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/01/04
Ainsliadimer C
interleukin-1 beta
macrophages
NLRP3 inflammasome
Sirtuin 1
adipose tissue inflammation
obesity
metabolic disorders
EX-527
dexamethasone
Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury
期刊论文
FASEB JOURNAL, 2021, 卷号: 35, 期号: 11, 页码: 17
作者:
Wu, Yong-Mei
;
Shi, Qing
;
Zhu, Peng-Fei
;
Ma, Hai-Jian
;
Cui, Shi-Chao
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/12/16
acute kidney injury
IKK/NF-kappa B
inflammation
macrophage
PI3K/PDK1/Akt
rhodomeroterpene
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125
作者:
Zhang, Huimin
;
He, Jixiao
;
Hu, Guang
;
Zhu, Fei
;
Jiang, Hao
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/04
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
期刊论文
GLYCOCONJUGATE JOURNAL, 2021, 页码: 11
作者:
Zeng, Jiaxin
;
Meng, Yuan
;
Chen, Shi-Yi
;
Zhao, Gaofeng
;
Wang, Lianchun
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/12/01
Furin
Heparan sulfate
Heparin
Virus infection
Carbohydrate-protein interaction
Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 10, 页码: 2260-2269
作者:
Yin, Jianpeng
;
Zhan, Desheng
;
Ma, Hui
;
Liu, Huanan
;
Yu, Lifang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/12/16
YLF466D
AMPK activator
glucose metabolism
lipid metabolism
MIRI
domino reaction
C-H activation
Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains
期刊论文
IMMUNITY, 2021, 卷号: 54, 期号: 10, 页码: 2218-+
作者:
Song, Bin
;
Chen, Yun
;
Liu, Xin
;
Yuan, Fei
;
Tan, Eddie Yong Jun
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/12/01
Stereo-selective synthesis of non-canonical gamma-hydroxy-alpha-amino acids by enzymatic carbon-carbon bond formation
期刊论文
CATALYSIS SCIENCE & TECHNOLOGY, 2021, 页码: 6
作者:
Zhang, Rui
;
Tan, Jiamu
;
Luo, Zhenzhen
;
Dong, Haihong
;
Ma, Ningshan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/12/01
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
Structures of full-length glycoprotein hormone receptor signalling complexes
期刊论文
NATURE, 2021, 页码: 24
作者:
Duan, Jia
;
Xu, Peiyu
;
Cheng, Xi
;
Mao, Chunyou
;
Croll, Tristan
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/11/04
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