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科研机构
上海药物研究所 [15]
内容类型
期刊论文 [11]
会议论文 [4]
发表日期
2021 [1]
2020 [2]
2019 [1]
2018 [3]
2017 [1]
2015 [2]
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Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200
期刊论文
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 页码: 10
作者:
Zhu, Shuhao
;
Gilbert, James C.
;
Liang, Zicai
;
Kang, Daiwu
;
Li, Ming
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
glycoprotein Ib
platelet
reversal agent
thrombosis
von Willebrand factor
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2018, 卷号: 31, 期号: 11, 页码: 1213-1218
作者:
Zhan, Zhengsheng
;
Peng, Xia
;
Sun, Yiming
;
Ai, Jing
;
Duan, Wenhu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
A bridging immunogenicity assay for monoclonal antibody: case study with SHR-1222
期刊论文
BIOANALYSIS, 2018, 卷号: 10, 期号: 14, 页码: 1115-1127
作者:
Zhang, Dan
;
Yang, Changyong
;
Chen, Xiaoyan
;
Li, Xiuli
;
Zhong, Dafang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
ADAs
anti-drug antibodies
bridging immunogenicity assay
monoclonal antibody (mAb)
SHR-1222
Species-Specific Involvement of Integrin alpha IIb beta 3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys
期刊论文
MOLECULAR THERAPY, 2018, 卷号: 26, 期号: 6, 页码: 1457-1470
作者:
Zhang, Yiting
;
Sun, Jianhua
;
Tan, Minjia
;
Liu, Yongzhen
;
Li, Qian
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Detecting drug-induced changes in ECG parameters using jacketed telemetry: Effect of different data reduction techniques
期刊论文
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2017, 卷号: 85, 页码: 38-48
作者:
Skinner, Matthew
;
Xing, Guozhen
;
Lu, Jing
;
Ren, Jin
;
Oldman, Karen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Data reduction
Electrocardiogram
Heart rate
Methods
Moxifloxacin
Non-human primate
Non-invasive telemetry
QT interval
Safety pharmacology
Super-interval
Effects of group housing on ECG assessment in conscious cynomolgus monkeys
期刊论文
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2015, 卷号: 75, 页码: 44-51
作者:
Xing, Guozhen
;
Lu, Jing
;
Hu, Miaomiao
;
Wang, Shaodong
;
Zhao, Li
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Electrocardiogram
Group housing
Heart rate
Methods
Moxifloxacin
Non-human primate
Non-invasive telemetry
QT interval
Safety pharmacology
Single housing
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
期刊论文
XENOBIOTICA, 2015, 卷号: 45, 期号: 3, 页码: 270-277
作者:
Yu, Hong
;
Barrass, Nigel
;
Gales, Sonya
;
Lenz, Eva
;
Parry, Tony
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Cynomolgus monkeys
detoxification by glucuronidation
paracetamol toxicity
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