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科研机构
上海药物研究所 [16]
内容类型
期刊论文 [16]
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2021 [1]
2019 [1]
2018 [1]
2015 [1]
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内容类型:期刊论文
专题:上海药物研究所
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Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease
期刊论文
REVIEWS IN THE NEUROSCIENCES, 2015, 卷号: 26, 期号: 1, 页码: 13-30
作者:
Guo, Xiaodan
;
Jiang, Wei
;
Li, Chenjing
;
Zhu, Zhiyuan
;
Shen, Xu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
acetyl cholinesterase
Alzheimer's disease
autophagy
beta-amyloid
ER stress
lifespan
multitarget
oxidative stress
secretase
tau protein
Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion
期刊论文
JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 卷号: 88, 期号: 4, 页码: 807-815
作者:
Wang, Juan
;
Zhang, Hai Yan
;
Tang, Xi Can
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
cerebral hypoperfusion
huperzine A
chronic hypoxia
inflammation
white matter
Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia
期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2008, 卷号: 175, 期号: 1-3, 页码: 396-402
作者:
Zhang, Hai Yan
;
Zheng, Chun Yan
;
Yan, Han
;
Wang, Zhi Fei
;
Tang, Li Li
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Huperzine A
Acetylcholinesterase inhibitor
beta-Amyloid
Mitochondrial dysfunction
Inflammation
Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia
期刊论文
JOURNAL OF NEUROCHEMISTRY, 2008, 卷号: 106, 期号: 4, 页码: 1594-1603
作者:
Wang, Zhi-Fei
;
Wang, Juan
;
Zhang, Hai-Yan
;
Tang, Xi-Can
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
acetylcholinesterase inhibitor
cholinergic antiinflammatory pathway
huperzine A
middle cerebral artery occlusion
nicotinic acetylcholine receptor
Pharmacodynamic study of FS-0311: A novel highly potent, selective acetylcholinesterase inhibitor
期刊论文
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2008, 卷号: 28, 期号: 2, 页码: 245-261
作者:
Wang, Zhi Fei
;
Yan, Jin
;
Fu, Yan
;
Tang, Xi Can
;
Feng, Song
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
huperzine B derivative
cholinesterase inhibitor
Alzheimer's disease
scopolamine
transient brain ischemia and reperfusion
water maze
beta-amyloid
antioxidant enzymes
oxygen-glucose deprivation
staurosporine
Huperzine a from Huperzia species - an ethnopharmacolgical review
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2007, 卷号: 113, 期号: 1, 页码: 15-34
作者:
Ma, Xiaoqiang
;
Tan, Changheng
;
Zhu, Dayuan
;
Gang, David R.
;
Xiao, Peigen
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
huperzine A
ZT-1
Alzheimer's disease
Huperzia serrata
huperziaceae
drug discovery
bioactivities
clinical trials
traditional chinese medicine
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