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浏览/检索结果: 共33条，第1-10条 帮助 限定条件 发表日期：2021     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Dong, Ying;  Tang, Bi-xi;  Wang, Qi;  Zhou, Li-wei;  Li, Cong 收藏  |  浏览/下载：77/0  |  提交时间：2022/01/04 idiopathic pulmonary fibrosis  DDRs  kinase inhibitor  indazole derivatives  XBLJ-13  nintedanib  bleomycin-induced pulmonary fibrosismouse model   Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：40/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence 期刊论文 CELL REPORTS, 2021, 卷号: 37, 期号: 5, 页码: 21 作者:  Zan, Gui-Ying;  Wang, Yu-Jun;  Li, Xue-Ping;  Fang, Jun-Fan;  Yao, Song-Yu 收藏  |  浏览/下载：46/0  |  提交时间：2021/12/16 The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206 作者:  Jiang, Yuchen;  Peng, Xia;  Ji, Yinchun;  Dai, Yang;  Fang, Yanfen 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/16 FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway 期刊论文 INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12 作者:  Wang, Lan;  Zhao, Danfeng;  Wang, Huan;  Wang, Lele;  Liu, Xiaohui 收藏  |  浏览/下载：62/0  |  提交时间：2021/12/01 Inflammation  Microglia  LPS  RNA-seq  JAK  STAT signaling pathway   Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125 作者:  Zhang, Huimin;  He, Jixiao;  Hu, Guang;  Zhu, Fei;  Jiang, Hao 收藏  |  浏览/下载：36/0  |  提交时间：2022/01/04 Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator 期刊论文 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 10, 页码: 2260-2269 作者:  Yin, Jianpeng;  Zhan, Desheng;  Ma, Hui;  Liu, Huanan;  Yu, Lifang 收藏  |  浏览/下载：36/0  |  提交时间：2021/12/16 YLF466D  AMPK activator  glucose metabolism  lipid metabolism  MIRI  domino reaction  C-H activation   TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery 期刊论文 DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455 作者:  Xiang, Shuang;  Song, Shukai;  Tang, Haotian;  Smaill, Jeff B.;  Wang, Aiqun 收藏  |  浏览/下载：23/0  |  提交时间：2021/12/01 Antibiotic resistance  Computational biology  Databases  In silico tools   Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK 期刊论文 CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263 作者:  Elksnis, Andris;  Schiffer, Tomas A.;  Palm, Fredrik;  Wang, Yun;  Cen, Jing 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/01