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浏览/检索结果: 共57条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14 作者:  He, Yu-Long;  Chen, Meng-Ting;  Wang, Ting;  Zhang, Ming-Ming;  Li, Ying-Xia 收藏  |  浏览/下载：63/0  |  提交时间：2021/11/04 Type 2 diabetes mellitus  Dual FABP4/5 inhibitors  Anti-lipolytic and anti-inflammatory effects  Metabolic stability  Anti-diabetic activities   SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy 期刊论文 JOURNAL OF CONTROLLED RELEASE, 2021, 卷号: 339, 页码: 297-306 作者:  Huang, Ying;  Wang, Lei;  Cheng, Zhiyang;  Yang, Biyu;  Yu, Jiahui 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/01 Antitumour  Chemotherapy  SN38  Drug delivery systems  Albumin   The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206 作者:   收藏  |  浏览/下载：29/0  |  提交时间：2021/12/16 Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13 作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/01 2,5-diphenyl-1,3,4-oxadiazole derivatives  SHP2  Inhibitors  Structure-activity relationships (SAR)   Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5 作者:  Wang, Leiming;  Li, Xin;  Cui, Hong;  Lei, Xinsheng;  Liu, Hongchun 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/01 Marine nature products  Plocabulin  PM060184  Synthesis  Antiproliferation   Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin 期刊论文 GLYCOCONJUGATE JOURNAL, 2021, 页码: 11 作者:  Zeng, Jiaxin;  Meng, Yuan;  Chen, Shi-Yi;  Zhao, Gaofeng;  Wang, Lianchun 收藏  |  浏览/下载：51/0  |  提交时间：2021/12/01 Furin  Heparan sulfate  Heparin  Virus infection  Carbohydrate-protein interaction   Drug target inference by mining transcriptional data using a novel graph convolutional network framework 期刊论文 PROTEIN & CELL, 2021, 页码: 21 作者:  Zhong, Feisheng;  Wu, Xiaolong;  Yang, Ruirui;  Li, Xutong;  Wang, Dingyan 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/01 drug target inference  transcriptomics  deep learning  experimental verification   5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19 作者:  Wang, Shuni;  Yang, Hong;  Su, Mingbo;  Lian, Fulin;  Cong, Zhanqing 收藏  |  浏览/下载：80/0  |  提交时间：2021/11/04 NSD2  Methyltransferase  HTS  Multiple myeloma  5-Aminonaphthalene derivatives  Inhibitor   Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663 作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong 收藏  |  浏览/下载：17/0  |  提交时间：2021/12/16