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科研机构
上海药物研究所 [349]
内容类型
期刊论文 [349]
发表日期
2021 [349]
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共349条,第1-10条
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发表日期:2021
内容类型:期刊论文
专题:上海药物研究所
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A simple and effective method for identification of Fraxini Cortex from different sources by multi-mode fingerprint combined with chemometrics
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 16
作者:
Long, Huali
;
Yao, Shuai
;
Tian, Wenshuai
;
Hou, Jinjun
;
Lei, Min
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
chemometrics
Fraxini Cortex
high-performance thin-layer chromatography
multi-mode fingerprint
ultra-high-performance liquid chromatography
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Accucopy: accurate and fast inference of allele-specific copy number alterations from low-coverage low-purity tumor sequencing data
期刊论文
BMC BIOINFORMATICS, 2021, 卷号: 22, 期号: 1, 页码: 18
作者:
Fan, Xinping
;
Luo, Guanghao
;
Huang, Yu S.
收藏
  |  
浏览/下载:216/0
  |  
提交时间:2021/05/24
Cancer genomics
Copy number alterations
Next-generation sequencing
Acceptor engineering of small-molecule fluorophores for NIR-II fluorescence and photoacoustic imaging
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 卷号: 9, 期号: 48, 页码: 9951-9960
作者:
Li, Yaxi
;
Zhou, Hongli
;
Bi, Renzhe
;
Li, Xiuting
;
Zha, Menglei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation
期刊论文
ACS CATALYSIS, 2021, 页码: 82-88
作者:
Li, Hanyuan
;
Wang, Mei-Ling
;
Liu, Yu-Wen
;
Li, Ling-Jun
;
Xu, Hui
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/18
C-C bond activation
enone
olefination
Pd-catalyzed
late-stage diversification
Rapid nucleic acid detection of Escherichia coli O157:H7 based on CRISPR/ Cas12a system
期刊论文
FOOD CONTROL, 2021, 卷号: 130, 页码: 8
作者:
Wang, Shujuan
;
Fan, Yiling
;
Feng, Zhen
;
Song, Minghui
;
Li, Qiongqiong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
CRISPR/Cas12a
Fe3O4@PDA@UiO-66-NH2
Nucleic acid
Detection Escherichia coli O157:H7
A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies
期刊论文
JOURNAL OF IMMUNOLOGICAL METHODS, 2021, 卷号: 499, 页码: 6
作者:
Song, Yakai
;
Deng, Xiaojie
;
Shi, Wei
;
Tang, Feng
;
Huang, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
FcRn
TR-FRET
mAb
ADC
Pharmacokinetics
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