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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Cinnamtannin D1 Protects Pancreatic beta-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo 期刊论文 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 卷号: 68, 期号: 45, 页码: 12617-12630 作者:  Wang, Xin-Yi;  Zhu, Bo-Rong;  Jia, Qi;  Li, Yi-Ming;  Wang, Ting 收藏  |  浏览/下载：23/0  |  提交时间：2021/05/24 cinnamtannin D1  pancreatic beta-cells  autophagy  apoptosis  type 2 diabetes   New cembrane-type diterpenoids from the South China Sea soft coral Sinularia crassa and their alpha-glucosidase inhibitory activity 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 104, 页码: 6 作者:  Wu, Meng-Jun;  Wang, Hong;  Jiang, Cheng-Shi;  Guo, Yue-Wei 收藏  |  浏览/下载：8/0  |  提交时间：2021/05/24 Sinularia crassa  Cembranoid  Modified Mosher's method  ECD calculation  alpha-Glucosidase inhibitor   Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文 MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15 作者:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu 收藏  |  浏览/下载：55/0  |  提交时间：2020/12/24 Salt-inducible kinase 1  Phanginin A  Phosphodiesterase 4  Gluconeogenesis  cAMP   Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12 作者:  Han, Fanghui;  Ning, Mengmeng;  Cao, Hua;  Ye, Yangliang;  Feng, Ying 收藏  |  浏览/下载：32/0  |  提交时间：2020/12/21 Soft drug  TGR5  GLP-1  Gallbladder-filling effects  Rapid metabolism  Carboxylic ester   Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16 作者:  Darbalaei, Sanaz;  Yuliantie, Elita;  Dai, Antao;  Chang, Rulue;  Zhao, Peishen 收藏  |  浏览/下载：19/0  |  提交时间：2020/12/21 G protein-coupled receptor  Glucagon-like peptide-1 receptor  Glucagon receptor  Biased agonism  Unimolecular dual agonist   DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice 期刊论文 DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988 作者:  Xu, Xu;  Wang, Wei;  Wang, Zhengyu;  Lv, Jianlu;  Xu, Xiaoju 收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24 DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者:  Huang, Jun-shang;  Guo, Bin-bin;  Wang, Gai-hong;  Zeng, Li-min;  Hu, You-hong 收藏  |  浏览/下载：54/0  |  提交时间：2020/12/24 type 2 diabetes  DGAT1 inhibitors  pancreatic beta-cells  apoptosis  ER stress  inflammation   Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856 作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu 收藏  |  浏览/下载：237/0  |  提交时间：2020/12/24 Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)  hepatic steatosis  insulin resistance  caspase-1  interleukin 18 (IL-18)  fatty liver  metabolic disorder  inflammation  cytokine signaling  caspase 1 (CASP1)  tyrosine-protein phosphatase (tyrosine phosphatase)  macrophage   Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Yu, Yan-yan;  Cui, Shi-chao;  Zheng, Tian-nan;  Ma, Hai-jian;  Xie, Zhi-fu 收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 insulin resistance  sarsasapogenin  adipose tissue inflammation  macrophage-adipocyte crosstalk  IKK/NF-kappa B  JNK   Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 12, 页码: 18 作者:  Han, Haozhen;  Li, Chunpu;  Li, Man;  Yang, Lisheng;  Zhao, Sen 收藏  |  浏览/下载：36/0  |  提交时间：2020/12/24 sirtuins  inhibitor  structure-activity relationship  deacetylase