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科研机构
上海药物研究所 [26]
内容类型
期刊论文 [26]
发表日期
2020 [26]
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浏览/检索结果:
共26条,第1-10条
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发表日期:2020
专题:上海药物研究所
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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases
期刊论文
MEDICINAL RESEARCH REVIEWS, 2020, 页码: 74
作者:
Panossian, Alexander G.
;
Efferth, Thomas
;
Shikov, Alexander N.
;
Pozharitskaya, Olga N.
;
Kuchta, Kenny
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
adaptogen
aging
ethnopharmacology
network pharmacology
stress
Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 卷号: 142, 期号: 42, 页码: 18005-18013
作者:
Chai, Xianzhi
;
Han, Hai-Hao
;
Sedgwick, Adam C.
;
Li, Na
;
Zang, Yi
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities
期刊论文
CHEMISTRY & BIODIVERSITY, 2020, 页码: 10
作者:
Hu, Yu-Hong
;
Liu, Jin
;
Li, Heng
;
Tang, Wei
;
Li, Xu-Wen
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/12/21
Citrus changshan-huyou
limonoids
structure modification
anti-inflammation
Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 19, 页码: 10972-10983
作者:
Ma, Yuqin
;
Luo, Qichao
;
Fu, Jie
;
Che, Yanxin
;
Guo, Fei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/05/24
Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada
期刊论文
FITOTERAPIA, 2020, 卷号: 146, 页码: 9
作者:
Hu, Zhi-Biao
;
Yu, Xiao-Qing
;
Wang, Bin
;
Liu, Ai-Hong
;
Zhao, Tian-Sheng
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/12/24
Laurencia composita
Chamigrane sesquiterpenoids
Bisabolane sesquiterpenoids
Nerolidol derivative
Modified Mosher's method
Antifungal activity
Antibacterial activity
The triterpenoid sapogenin (2 alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling
期刊论文
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 9, 页码: 10
作者:
Xie, Zhifu
;
Jiang, Haowen
;
Liu, Wei
;
Zhang, Xinwen
;
Chen, Dakai
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 15, 页码: 8134-8145
作者:
Chen, Wuhong
;
Liu, Feifei
;
Zhao, Qiliang
;
Ma, Xinna
;
Lu, Dong
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/12/24
YES1amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer
期刊论文
BRITISH JOURNAL OF CANCER, 2020, 页码: 12
作者:
Wang, Lei
;
Wang, Quanren
;
Xu, Piaopiao
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 卷号: 60, 期号: 6, 页码: 3265-3276
作者:
Zhao, Wenfeng
;
Xiong, Muya
;
Yuan, Xiaojing
;
Li, Minjun
;
Sun, Hongbin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
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