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浏览/检索结果: 共19条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 21, 页码: 12748-12772 作者:  Li, Junyou;  Liu, Mengqi;  Li, Yazhou;  Sun, Dan-dan;  Shu, Zhihao 收藏  |  浏览/下载：22/0  |  提交时间：2021/05/24 Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文 MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15 作者:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu 收藏  |  浏览/下载：55/0  |  提交时间：2020/12/24 Salt-inducible kinase 1  Phanginin A  Phosphodiesterase 4  Gluconeogenesis  cAMP   Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases 期刊论文 ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 10, 页码: 1966-1976 作者:  Zhao, Yuge;  Yang, Yuting;  Zhang, Jiaxin;  Wang, Rong;  Cheng, Biyun 收藏  |  浏览/下载：26/0  |  提交时间：2020/12/24 Targeting delivery  Macrophages  Patchouli alcohol  Liposome  Inflammatory bowel disease  Colitis   Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Li, Bo-han;  Zhang, Mei;  Duan, Ya-nan;  Shuai, Lin;  Jiang, Hao-wen 收藏  |  浏览/下载：50/0  |  提交时间：2020/12/21 AMP-activated protein kinase  pyrazolone derivative C29  obesity  energy expenditure  thermogenesis  inguinal white adipose tissue  white adipose browning   Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi 收藏  |  浏览/下载：82/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy 期刊论文 CELL DEATH AND DIFFERENTIATION, 2020, 页码: 17 作者:  Guo, Huijie;  Pu, Mei;  Tai, Yusi;  Chen, Yuxiang;  Lu, Henglei 收藏  |  浏览/下载：54/0  |  提交时间：2020/12/24 AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者:  Sun, Shui-mei;  Xie, Zhi-fu;  Zhang, Yang-ming;  Zhang, Xin-wen;  Zhou, Chen-dong 收藏  |  浏览/下载：25/0  |  提交时间：2020/12/24 adenosine 5 '-monophosphate-activated protein kinase  AMPK activator  C24  liver  triglycerides  cholesterol  VLDL  hypolipidemic drug  metabolic syndrome   USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines 期刊论文 FEBS JOURNAL, 2020, 页码: 18 作者:  Wang, Hui;  Meng, Qian;  Ding, Yiluan;  Xiong, Muya;  Zhu, Mengying 收藏  |  浏览/下载：84/0  |  提交时间：2020/12/24 colorectal cancer  HDX-MS  inhibitor  USP25  USP28  Vismodegib   Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer 期刊论文 CANCER CELL, 2020, 卷号: 38, 期号: 1, 页码: 115-+ 作者:  Tang, Yang;  Fang, Gemin;  Guo, Fenghua;  Zhang, Hui;  Chen, Xiaoxu 收藏  |  浏览/下载：95/0  |  提交时间：2020/12/24 DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Chen, Xiang-ling;  Liu, Peng;  Zhu, Wei-liang;  Lou, Li-guang 收藏  |  浏览/下载：50/0  |  提交时间：2020/07/01 DCZ5248  Hsp90  autophagy  lysosomal function  antitumor activity  colon cancer