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浏览/检索结果: 共5条，第1-5条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230 作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang 收藏  |  浏览/下载：46/0  |  提交时间：2020/07/01 PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16 作者:  He, Yulong;  Dou, Huixia;  Gao, Dingding;  Wang, Ting;  Zhang, Mingming 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 Dual FABP4/5 inhibitor  Structure-based design  Lipolysis inhibition  Anti-inflammatory effects   (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice 期刊论文 LIFE SCIENCES, 2019, 卷号: 232, 页码: 9 作者:  Dong, Yunxia;  Lu, Henglei;  Li, Qiang;  Qi, Xinming;  Li, Yuanchao 收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 (5R)-5-hydroxytriptolide  NAFLD  Lipid synthesis  Fatty acids oxidation  Fat deposition   Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature 期刊论文 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2019, 卷号: 74, 期号: 1, 页码: 1-8 作者:  Bacalini, Maria Giulia;  Franceschi, Claudio;  Gentilini, Davide;  Ravaioli, Francesco;  Zhou, Xiaoyuan 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 DNA methylation  Epigenetic clock  Epithelialmesenchymal transition   designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文 actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216 作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang 收藏  |  浏览/下载：52/0  |  提交时间：2020/07/01 DOPAMINE D-1  BERBERINE  EXPRESSION  INHIBITORS  IDENTIFICATION  CHOLESTEROL  MUTATIONS  LDLR  PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster