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浏览/检索结果: 共15条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer 期刊论文 PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11 作者:  Wang Yuwei;  Tang Chunping;  Yao Sheng;  Lai Huanling;  Li Runze 收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01 Non-small cell lung cancer  Natural product  Croton tiglium  Protein kinase C  Molecular modelling   Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor 期刊论文 SMALL, 2019, 页码: 13 作者:  Lai, Yi;  Xu, Zhiai;  Hu, Xianli;  Lei, Li;  Li, Lingling 收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01 biomineralization  cancer metastasis  combination therapy  Fenton reaction  peptide nanotubes   Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 10, 页码: 4303-4318 作者:  Chen, Jianzhong;  Wang, Jinan;  Yin, Baohua;  Pang, Laixue;  Wang, Wei 收藏  |  浏览/下载：114/0  |  提交时间：2020/07/01 beta-amyloid cleaving enzyme  binding selectivity  MSMD  hierarchical clustering analysis  MM-GBSA   Identification of a new inhibitor of KRAS-PDE delta interaction targeting KRAS mutant nonsmall cell lung cancer 期刊论文 INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 5, 页码: 1334-1345 作者:  Leung, Elaine Lai-Han;  Luo, Lian Xiang;  Li, Ying;  Liu, Zhong-Qiu;  Li, Lan Lan 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods 期刊论文 FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 11 作者:  Wang, Dingyan;  Cui, Chen;  Ding, Xiaoyu;  Xiong, Zhaoping;  Zheng, Mingyue 收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01 virtual screening  target-specific scoring function  deep learning  drug discovery  DUD-E   Pharmacological characterization of TQ05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants 期刊论文 CANCER SCIENCE, 2019, 页码: 9 作者:  Gao, Mingzhao;  Zhu, Hongmei;  Fu, Li;  Li, Yun;  Bao, Xubin 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 AG-221  IDH2  leukemia  R140Q  R172K   Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation 期刊论文 MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21 作者:  Jiang, Cheng-Shi;  Ge, Yong-Xi;  Cheng, Zhi-Qiang;  Wang, Yin-Yin;  Tao, Hong-Rui 收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01 selective BChE inhibitor  virtual screening  structural optimization  molecular dynamics  anti-A beta aggregation   SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979 作者:  Yang, Chang-yong;  Wang, Lei;  Sun, Xing;  Tang, Mi;  Quan, Hai-tian 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 SHR-A1403  c-Met ADC  anti-tumor  patient-derived xenograft (PDX)  molecular mechanisms   Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593 作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family 期刊论文 FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17 作者:  Li, Fei;  Wan, Xiaozhe;  Xing, Jing;  Tan, Xiaoqin;  Li, Xutong 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 deep neural network  virtual screening  methyltransferase  epigenetic  drug design