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上海药物研究所 [15]
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期刊论文 [46]
发表日期
2018 [46]
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Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma
期刊论文
Bioorganic & medicinal chemistry letters, 2018
作者:
Zhou, Ruolan
;
Fang, Shaoyu
;
Zhang, Minmin
;
Zhang, Qingsen
;
Hu, Jian
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Alterations of early-stage decomposition of leaves and absorptive roots by deposition of nitrogen and phosphorus have contrasting mechanisms
期刊论文
SOIL BIOLOGY & BIOCHEMISTRY, 2018, 卷号: 127, 页码: 213-222
作者:
Jiang, Lei
;
Kou, Liang
;
Li, Shenggong
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  |  
浏览/下载:36/0
  |  
提交时间:2019/05/23
Litter decomposition
Nutrient deposition
AUR
Phosphorus limitation
Nitrogen addition
Microbial enzymatic activity
Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1885-1893
作者:
Fang, Tian
;
Liu, Dan-Dan
;
Ning, He-Ming
;
Sun, Jing-Ya
;
Huang, Xiao-Jing
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  |  
浏览/下载:71/0
  |  
提交时间:2019/01/08
VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2018, 卷号: 129, 页码: 177-185
作者:
Zhou, Ling
;
Yi, Yuetao
;
Yuan, Qing
;
Zhang, Jing
;
Li, Youjie
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  |  
浏览/下载:19/0
  |  
提交时间:2020/07/08
Vanadyl alginate oligosaccharides
Non-small cell lung cancer
ROS
AKT
PTEN
Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage
期刊论文
PARTICLE AND FIBRE TOXICOLOGY, 2018, 卷号: 15, 页码: 45
作者:
Xu, Lina
;
Dai, Yanhui
;
Wang, Zhenyu
;
Zhao, Jian
;
Li, Fei
收藏
  |  
浏览/下载:197/0
  |  
提交时间:2020/07/08
Aminated graphene quantum dots
Macrophages
Endocytosis
Nuclear accumulation
DNA cleavage
Molecular docking
Rapid re-evaluation of bioactive saponins from Paris polyphylla using affinity ultrafiltration-LC/MS with multiple drug targets
期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2018, 卷号: 434, 页码: 87-92
作者:
Guo, Mingquan
;
Chen, Guilin
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  |  
浏览/下载:58/0
  |  
提交时间:2018/12/29
Ultrafiltration-LC/MS
Polyphyllin
Topoisomerase I and II
Cyclooxygenase 2
Multiple drug targets
Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 卷号: 161, 页码: 1-7
作者:
Li, Hao
;
Ji, Zhihua
;
Zhang, Yaxian
;
Tian, Juan
;
Wang, Fengbang
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  |  
浏览/下载:25/0
  |  
提交时间:2019/06/20
Tetrachlorobisphenol A
Cytotoxicity
Saccharomyces cerevisiae
Oxidative stress
STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 10, 页码: 3305-3315
作者:
Wang, Lei
;
Wang, Quanren
;
Gao, Mingzhao
;
Fu, Li
;
Li, Yun
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
drug resistance
leukemia inhibitory factor receptor
secreted factor
STAT3
trastuzumab-emtansine
Phosphate affects adsorption and desorption of oxytetracycline in the seawater-sediment systems
期刊论文
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2018, 卷号: 25, 期号: 28 SI, 页码: 28160-28168
作者:
Li, Jia
;
Zhang, Hua
;
Yuan, Guodong
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  |  
浏览/下载:15/0
  |  
提交时间:2020/07/08
Oxytetracycline
Phosphate
Sorption
desorption
Salinity
Combined effects
Kinetics
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