Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells

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	Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells
	Li, Hao; Ji, Zhihua; Zhang, Yaxian; Tian, Juan; Wang, Fengbang; Song, Maoyong
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2018-10-15
卷号	161 页码:1-7
关键词	Tetrachlorobisphenol A Cytotoxicity Saccharomyces cerevisiae Oxidative stress
ISSN号	0147-6513
文献子类	Article
英文摘要	Tetrachlorobisphenol A (TCBPA), which is widely used as flame retardant, can be released into various environments, thereby being absorbed by wildlife or human beings through food chain's bio-magnification and causing some adverse influences on wildlife or human beings. However, limited data are currently available on TCBPA-associated cytotoxicity and related mechanisms. Here, the cytotoxicity induced by different concentrations of TCBPA (i.e., 5, 10 and 20 mu M) was studied using Saccharomyces cerevisiae, a simple eukaryotic model organism. TCBPA treatment inhibited the growth and survival rate of yeast cell in a dose-dependent manner. Moreover, TCBPA promoted the increasing of intracellular oxidative stress by enhancing accumulation of intracellular reactive oxygen species (ROS). Meanwhile, lipid peroxidation degree (represented by malondialdehyde (MDA) content) and DNA damage degree (represented by 8-hydroxy deoxyguanosine (8-oxodG) content) in yeast cell also increased after TCBPA treatment. However, yeast cell mitochondrial membrane potential (Delta psi m) decreased after TCBPA treatment. It was noteworthy that there was no significant inhibitory effect on yeast cell growth or survival rate in 5 mu M TCBPA-treated cells, but the intracellular MDA content and Delta psi m level changed significantly, suggesting the potential cell damage secondary to the relative low dose of TCBPA exposure. Results presented here would highlight our knowledge about TCBPA-associated cytotoxicity in organisms.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41098]
专题	生态环境研究中心_环境纳米材料实验室
推荐引用方式 GB/T 7714	Li, Hao,Ji, Zhihua,Zhang, Yaxian,et al. Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,161:1-7.
APA	Li, Hao,Ji, Zhihua,Zhang, Yaxian,Tian, Juan,Wang, Fengbang,&Song, Maoyong.(2018).Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,161,1-7.
MLA	Li, Hao,et al."Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 161(2018):1-7.