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上海药物研究所 [23]
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大连化学物理研究所 [5]
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期刊论文 [80]
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2018 [82]
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Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699
作者:
Zhu, Kongkai
;
Song, Jia-Li
;
Tao, Hong-Rui
;
Cheng, Zhi-Qiang
;
Jiang, Cheng-Shi
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/01/08
Pharmacophore combination
Isoquinoline
PRMT5 inhibitor
Molecular docking
Molecular dynamics simulation
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Wang, Anhui
;
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/06/20
beta(2)-Adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
Naunyn-schmiedebergs archives of pharmacology, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
;
Qu, Lala
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/05/08
Beta(2)-adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:
Zhu, Kongkai
;
Tao, Hongrui
;
Song, Jia-Li
;
Jin, Lu
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:130/0
  |  
提交时间:2019/01/08
PRMT5 inhibitor
Arginine methylation
Virtual screening
Molecular docking
Molecular dynamics simulation
Investigate the mechanisms of Chinese medicine Fuzhengkangai towards EGFR mutation-positive lung adenocarcinomas by network pharmacology
期刊论文
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 卷号: 18, 页码: 17
作者:
Bing, Zhitong
;
Cheng, Zhiyuan
;
Shi, Danfeng
;
Liu, Xinkui
;
Tian, Jinhui
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  |  
浏览/下载:91/0
  |  
提交时间:2019/10/09
Systems pharmacology
Fuzhengkangai formula
Herbal medicines
Molecular docking
Investigate the mechanisms of Chinese medicine Fuzhengkangai towards EGFR mutation-positive lung adenocarcinomas by network pharmacology
期刊论文
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 卷号: 18
作者:
Bing, Zhitong
;
Cheng, Zhiyuan
;
Shi, Danfeng
;
Liu, Xinkui
;
Tian, Jinhui
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/03/27
Systems pharmacology
Fuzhengkangai formula
Herbal medicines
Molecular docking
Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR
期刊论文
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873
作者:
Li, R.
;
Du, Y.
;
Shen, J.
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  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
BTK inhibitors
B-cell malignancies
molecule docking
3D-QSAR
CoMFA
CoMSIA
Rapid re-evaluation of bioactive saponins from Paris polyphylla using affinity ultrafiltration-LC/MS with multiple drug targets
期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2018, 卷号: 434, 页码: 87-92
作者:
Guo, Mingquan
;
Chen, Guilin
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  |  
浏览/下载:58/0
  |  
提交时间:2018/12/29
Ultrafiltration-LC/MS
Polyphyllin
Topoisomerase I and II
Cyclooxygenase 2
Multiple drug targets
Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L
期刊论文
Biomedical chromatography : BMC, 2018, 卷号: 32, 期号: 11, 页码: e4328
作者:
Chen, Zhiyong
;
Du, Xia
;
Yang, Yuanyuan
;
Cui, Xiaomin
;
Zhang, Zijia
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  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 302-310
作者:
Peng, Jingjing
;
Zhao, Lifen
;
Wang, Lanlan
;
Chen, Hui
;
Qiu, Yunguang
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
P2Y(1) receptor antagonist
2-(phenoxyaryl)-3-urea derivatives
Anti-Platelet
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