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上海药物研究所 [63]
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期刊论文 [424]
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Revealing transcription factor and histone modification co-localization and dynamics across cell lines by integrating ChIP-seq and RNA-seq data
期刊论文
BMC GENOMICS, 2018, 卷号: 19, 页码: 16
作者:
Zhang, Lirong
;
Xue, Gaogao
;
Liu, Junjie
;
Li, Qianzhong
;
Wang, Yong
收藏
  |  
浏览/下载:221/0
  |  
提交时间:2019/01/11
Transcription factor
Histone modification
Co-localization
Dynamics
Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4(+) T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4
期刊论文
FRONTIERS IN IMMUNOLOGY, 2018, 卷号: 9, 页码: 15
作者:
Hu, Qinxue
;
Gong, Sitang
;
Liu, Yalan
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  |  
浏览/下载:125/0
  |  
提交时间:2019/03/05
HSV-2
CXCR3 ligands
CD4(+) T cells
recruitment
ICP4
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699
作者:
Zhu, Kongkai
;
Song, Jia-Li
;
Tao, Hong-Rui
;
Cheng, Zhi-Qiang
;
Jiang, Cheng-Shi
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Pharmacophore combination
Isoquinoline
PRMT5 inhibitor
Molecular docking
Molecular dynamics simulation
Effect of Pore Structure on Protein Capacity in Macroporous Polymer Chromatographic Supports
期刊论文
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2018, 卷号: 39, 期号: 12, 页码: 2673-2678
作者:
Li Heng
;
Wang Shaoyun
;
Fang Jiaxuan
;
Zhao Lan
;
Jin Haibo
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  |  
浏览/下载:57/0
  |  
提交时间:2019/04/03
Macroporous Polymer Microsphere
Chromatographic Media
Protein Capactiy
High Through-put
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Combinational biosynthesis and characterization of fusion proteins with tandem repeats of allophycocyanin holo-alpha subunits, and their application as bright fluorescent labels for immunofluorescence assay
期刊论文
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2018, 卷号: 126, 期号: 6, 页码: 778-782
作者:
Chen, Huaxin
;
Jiang, Peng
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浏览/下载:223/0
  |  
提交时间:2019/05/15
Allophycocyanin
Streptavidin
Fusion protein
Fluorescence
Immunofluorescence assay
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Wang, Anhui
;
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
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  |  
浏览/下载:55/0
  |  
提交时间:2019/06/20
beta(2)-Adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis
期刊论文
RNA, 2018, 卷号: 24, 期号: 12, 页码: 1738-1748
作者:
He, Wen-Xia
;
Wu, Min
;
Liu, Zhen
;
Li, Zhi
;
Wang, Yang
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  |  
浏览/下载:70/0
  |  
提交时间:2019/07/02
slbp2
replication-dependent histones
ribosomal proteins
maternal effect
oogenesis
early embryogenesis
Expression and DNA methylation analysis of cyp19a1a in Chinese sea perch Lateolabrax maculatus
期刊论文
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2018, 卷号: 226, 页码: 85-90
作者:
Chen, Xiaowu
;
He, Yudong
;
Wang, Zhipeng
;
Li, Jun
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  |  
浏览/下载:165/0
  |  
提交时间:2019/08/27
cyp19a1a
DNA methylation
Expression pattern
Lateolabrax maculatus
Promoter
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
Naunyn-schmiedebergs archives of pharmacology, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
;
Qu, Lala
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/05/08
Beta(2)-adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
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