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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design and synthesis of C-10 modified and ring-truncated canthin-6-one analogues as effective membrane-active antibacterial agents 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 18, 页码: 3123-3128 作者:  Dai, Jiangkun;  Dan, Wenjia;  Zhang, Yunyun;  He, Mengfan;  Wang, Junru 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Canthin-6-one  Synthesis  Antibacterial activity  Structure-activity relationships  Mechanism   3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 18, 页码: 8136-8154 作者:  Baqi, Younis;  Pillaiyar, Thanigaimalai;  Abdelrahman, Aliaa;  Kaufmann, Olesja;  Aishaibani, Samer 收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08 Synthesis and antibacterial activity of C-2 or C-5 modified and D ring rejiggered canthin-6-one analogues 期刊论文 FOOD CHEMISTRY, 2018, 卷号: 253, 页码: 211-220 作者:  Dai, Jiangkun;  Dan, Wenjia;  Li, Nian;  Wang, Ruixue;  Zhang, Yao 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Synthesis  Canthin-6-one analogues  Antibacterial  Structure-activity relationships  Cell membrane  DNA topoisomerases   Jatrophanes as promising multidrug resistance modulators: Advances of structure-activity relationships 期刊论文 FITOTERAPIA, 2018, 卷号: 127, 页码: 138-145 作者:  Li, Jun;  Wang, Wen-qiong;  Tang, Shuai;  Song, Wei-bin;  Xuan, Li-jiang 收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 Euphorbia helioscopia  Multidrug resistance  Jatrophanes   Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317 作者:  Ma, Fei;  Liu, Jian;  Zhou, Tingting;  Lei, Min;  Chen, Jing 收藏  |  浏览/下载：79/0  |  提交时间：2019/01/08 Thienol2,3-b]pyridine derivatives  Structure-activity relationships (SARs)  Hepatic gluconeogenesis  Type 2 diabetes mellitus (T2DM)   Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758 作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 DOT1L  MLL-rearranged leukemia  AlphaLISA  HTS  Novel inhibitors   Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK) 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027 作者:  Gu, Zhanni;  Wu, Lingyan;  Duan, Yanan;  Wang, Jiang;  Zhou, Shengbin 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Adenosine 5 '-monophosphate-activated protein kinase  AMPK activators  Berberine  Tetrahydroberberine  T2DM   Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 235-251 作者:  Wei, Hanwen;  Mao, Fei;  Ni, Shuaishuai;  Chen, Feifei;  Li, Baoli 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 CrtN inhibitor  STX biosynthesis  Pigment inhibitory activity  Resistant S. aureus   Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 622-633 作者:  Sun, Guanglong;  Wang, Junwei;  Guo, Xiaodan;  Lei, Min;  Zhang, Yinan 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 LX2343 derivatives  Neuroprotective agents  Alzheimer's disease  Structural modifications  Structure-activity relationships   Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 2, 页码: 94-102 作者:  Ding, Shi;  Dai, Rui-Yang;  Wang, Wen-Ke;  Cao, Qiao;  Lan, Le-Fu 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Gram-negative bacteria infection  LpxC inhibitor  Structure-activity relationship  Zinc binding group  Liver microsomal stability