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浏览/检索结果: 共15条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812 作者:  Zheng, Qiangang;  Chen, Ziqi;  Wan, Huixin;  Tang, Shuai;  Ye, Yan 收藏  |  浏览/下载：234/0  |  提交时间：2019/01/08 IDH1 inhibitor  Imidazole cyclopropyl amine  Structure-based rational design   Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：86/0  |  提交时间：2019/01/08 Synthesis of androgen receptor antagonists containing a pentafluorosulfanyl (SF5) moiety 期刊论文 ARCHIV DER PHARMAZIE, 2018, 卷号: 351, 期号: 11 作者:  Jin, Jiyu;  Zhou, Yan;  Yang, Dehua;  Zhang, Qiumeng;  Wang, Ming-Wei 收藏  |  浏览/下载：71/0  |  提交时间：2019/01/08 androgen receptor  antagonist  enzalutamide  pentafluorosulfanyl   Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Su, Haixia;  Xu, Yechun 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 ITC  thermodynamics  kinetics  protein-ligand recognition  drug design   Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis 期刊论文 ADVANCED FUNCTIONAL MATERIALS, 2018, 卷号: 28, 期号: 40 作者:  Zhang, Zhiwen;  Wang, Hong;  Tan, Tao;  Li, Jie;  Wang, Zhiwan 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 drug delivery  metastasis  nanoparticles  penetration  tumors   Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents 期刊论文 ACS chemical neuroscience, 2018 作者:  Xu, Yixiang;  Zhang, Jian;  Wang, Huan;  Mao, Fei;  Bao, Keting 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Current Strategies and Applications for Precision Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Wang, Chen;  Xu, Pan;  Zhang, Luyu;  Huang, Jing;  Zhu, Kongkai 收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08 precision medicine  precision drug design  computational modeling  deep learning  antibody-drug conjugates  ligand-targeted conjugates   Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy 期刊论文 CHEMICAL SCIENCE, 2018, 卷号: 9, 期号: 22, 页码: 4959-4969 作者:  Yan, Chenxu;  Guo, Zhiqian;  Shen, Yanyan;  Chen, Yi;  Tian, He 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors 期刊论文 MOLECULES, 2018, 卷号: 23, 期号: 3 作者:  Jiang, Alan;  Liu, Qiufeng;  Wang, Ruifeng;  Wei, Peng;  Dai, Yang 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 cancer  FGFR  kinase inhibitor  pyrrolo[2,3-b]pyrazine   Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy 期刊论文 NANO LETTERS, 2018, 卷号: 18, 期号: 3, 页码: 1908-1915 作者:  Zhang, Yu;  Gai, Kaimin;  Li, Chao;  Guo, Qin;  Chen, Qinjun 收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08 tumor microenvironment  macrophage-membrane coating  cascade-responsiveness  biomimetic delivery system  breast-cancer targeting