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科研机构
上海药物研究所 [5]
北京大学 [2]
西安交通大学 [2]
山东大学 [2]
河北省人民医院 [2]
武汉大学 [2]
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期刊论文 [26]
发表日期
2017 [26]
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Engineerin... [1]
Materials ... [1]
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Dihydroartemisinin selectively inhibits PDGFR alpha-positive ovarian cancer growth and metastasis through inducing degradation of PDGFR alpha protein
期刊论文
CELL DISCOVERY, 2017, 卷号: 3
作者:
Li, Xiaoguang
;
Ba, Qian
;
Liu, Yanling
;
Yue, Qingxi
;
Chen, Peizhan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Dihydroartemisinin
Epithelial-mesenchymal transition
metastasis
ovarian cancer
PDGFR alpha
New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Yang, Xiuyan
;
Zhang, Xi
;
Huang, Min
;
Song, Kun
;
Li, Xuefen
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant
期刊论文
ELSEVIER SCI LTD, 2017, 卷号: 63, 页码: 369-382
作者:
Zhang, Xiuzhi
;
Zu, Haiyue
;
Zhao, Dewei
;
Yang, Ke
;
Tian, Simiao
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2018/01/10
Biodegradable Magnesium Implants
Osteoinduction
Trpm7
Alkaline Stress
Osteonecrosis Of Femoral Head
Kinases Involved in Both Autophagy and Mitosis
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 9, 页码: 1-15
作者:
Li, Zhiyuan
;
Zhang, Xin
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2018/08/17
Kinases
Autophagy
Mitosis
Cyclin-dependent Kinases
Aurora
Polo-like Kinases
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 875-880
作者:
Yang, Chengbin
;
Zhang, Xi
;
Wang, Yi
;
Yang, Yongtai
;
Liu, Xiaofeng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
PI3K
PI3K/mTOR
oncology
1H-pyrrolo[2,3-b] pyridine
cancer therapy
Puquitinib, a novel orally available PI3K inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia
期刊论文
CANCER SCIENCE, 2017, 卷号: 108, 期号: 7, 页码: 1476-1484
作者:
Xie, Chengying
;
He, Ye
;
Zhen, Mingyue
;
Wang, Yulan
;
Xu, Yongping
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Acute myeloid leukemia
CAL-101
PI3K signaling
PI3K
puquitinib
SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1156-1171
作者:
Wei, Manman
;
Zhang, Xi
;
Wang, Xiang
;
Song, Zilan
;
Ding, Jian
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Chronic lymphocytic leukemia
PI3K delta
Structure-activity relationship
5-Alkynyl
Quinazolinone
The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments
期刊论文
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2017, 卷号: 64
作者:
Wang, William
;
Lv, Jiapei
;
Wang, Lingyan
;
Wang, Xiangdong
;
Ye, Ling
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
PIK3CA
Heterogeneity
Lung cancer
PI3K signaling pathway
Human cancer
Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB
期刊论文
Life Sciences, 2017, 卷号: 191, 页码: 115-121
作者:
Deng, Hua-Fei
;
Wang, Xiao-Li
;
Sun, Hui
;
Xiao, Xian-Zhong*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Endothelial cells
Mitogen-activated protein kinases
Nuclear factor-kappaB
Oxidative low-density lipoprotein
Phosphoinositide 3-kinase/Akt/endothelial nitric oxide synthase
Puerarin
Tissue factor
BDNF-GSK-3 beta-beta-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats
期刊论文
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2017
Xu, Ling-Zhi
;
Xu, De-Feng
;
Han, Ying
;
Liu, Li-Jing
;
Sun, Cheng-Yu
;
Deng, Jia-Hui
;
Zhang, Ruo-Xi
;
Yuan, Ming
;
Zhang, Su-Zhen
;
Li, Zhi-Meng
;
Xu, Yi
;
Li, Jin-Sheng
;
Xie, Su-Hua
;
Li, Su-Xia
;
Zhang, Hong-Yan
;
Lu, Lin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2017/12/03
Morinda officinalis oligosaccharides
depression
GSK-3 beta, beta-catenin
BDNF
GLYCOGEN-SYNTHASE KINASE-3
RETRIEVAL-EXTINCTION PROCEDURE
MEDIAL PREFRONTAL CORTEX
NUCLEUS-ACCUMBENS CORE
CHRONIC MILD STRESS
BETA-CATENIN
BASOLATERAL AMYGDALA
DEPRESSED-PATIENTS
SIGNALING PATHWAY
PC12 CELLS
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