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	BDNF-GSK-3 beta-beta-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats
	Xu, Ling-Zhi ; Xu, De-Feng ; Han, Ying ; Liu, Li-Jing ; Sun, Cheng-Yu ; Deng, Jia-Hui ; Zhang, Ruo-Xi ; Yuan, Ming ; Zhang, Su-Zhen ; Li, Zhi-Meng ; Xu, Yi ; Li, Jin-Sheng ; Xie, Su-Hua ; Li, Su-Xia ; Zhang, Hong-Yan ; Lu, Lin
刊名	INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
	2017
关键词	Morinda officinalis oligosaccharides depression GSK-3 beta, beta-catenin BDNF GLYCOGEN-SYNTHASE KINASE-3 RETRIEVAL-EXTINCTION PROCEDURE MEDIAL PREFRONTAL CORTEX NUCLEUS-ACCUMBENS CORE CHRONIC MILD STRESS BETA-CATENIN BASOLATERAL AMYGDALA DEPRESSED-PATIENTS SIGNALING PATHWAY PC12 CELLS
DOI	10.1093/ijnp/pyw088
英文摘要	Background: Morinda officinalis oligosaccharides have been reported to exert neuroprotective and antidepressant-like effects in the forced swim test in mice. However, the mechanisms that underlie the antidepressant-like effects of Morinda officinalis oligosaccharides are unclear. Methods: Chronic unpredictable stress and forced swim test were used to explore the antidepressant-like effects of Morinda officinalis oligosaccharides and resilience to stress in rats. The phosphoinositide-3 kinase inhibitor LY294002 was microinjected in the medial prefrontal cortex to explore the role of glycogen synthase kinase-3 beta in the antidepressant-like effects of Morinda officinalis oligosaccharides. The expression of brain-derived neurotrophic factor, phosphorylated-Ser9-glycogen synthase kinase 3 beta, beta-catenin, and synaptic proteins was determined in the medial prefrontal cortex and the orbitofrontal cortex by western blot. Results: We found that Morinda officinalis oligosaccharides effectively ameliorated chronic unpredictable stress-induced depression-like behaviors in the sucrose preference test and forced swim test. The Morinda officinalis oligosaccharides also significantly rescued chronic unpredictable stress-induced abnormalities in the brain-derived neurotrophic factor-glycogen synthase kinase-3 beta-beta-catenin pathway and synaptic protein deficits in the medial prefrontal cortex but not orbitofrontal cortex. The activation of glycogen synthase kinase-3 beta by the phosphoinositide-3 kinase inhibitor LY294002 abolished the antidepressant-like effects of Morinda officinalis oligosaccharides in the forced swim test. Naive rats that were treated with Morinda officinalis oligosaccharides exhibited resilience to chronic unpredictable stress, accompanied by increases in the expression of brain-derived neurotrophic factor, phosphorylated-Ser9-glycogen synthase kinase-3 beta, and beta-catenin in the medial prefrontal cortex. Conclusion: Our findings indicate that the brain-derived neurotrophic factor-glycogen synthase kinase-3 beta-beta-catenin pathway in the medial prefrontal cortex may underlie the antidepressant-like effect of Morinda officinalis oligosaccharides and resilience to stress.; National Natural Science Foundation of China [81171251]; National New Drug Innovation Program [2014ZH09301307-014]; SCI(E); PubMed; ARTICLE; 1; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/457460]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, Ling-Zhi,Xu, De-Feng,Han, Ying,et al. BDNF-GSK-3 beta-beta-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2017.
APA	Xu, Ling-Zhi.,Xu, De-Feng.,Han, Ying.,Liu, Li-Jing.,Sun, Cheng-Yu.,...&Lu, Lin.(2017).BDNF-GSK-3 beta-beta-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY.
MLA	Xu, Ling-Zhi,et al."BDNF-GSK-3 beta-beta-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2017).

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