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科研机构
湖南大学 [4]
上海药物研究所 [3]
新疆理化技术研究所 [2]
上海中医药大学 [2]
湖南中医药大学 [2]
厦门大学 [1]
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期刊论文 [20]
学位论文 [1]
发表日期
2017 [21]
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Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Rare Hybrid Dimers with Anti-Acetylcholinesterase Activities from a Safflower (Carthamus tinctorius L.) Seed Oil Cake
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 卷号: 65, 期号: 43, 页码: 9453-9459
作者:
Peng, Xing-Rong
;
Wang, Xia
;
Dong, Jin-Run
;
Qin, Xu-Jie
;
Li, Zhong-Rong
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  |  
浏览/下载:24/0
  |  
提交时间:2017/12/18
Safflower Seed Oil Cake
Carthamus Tinctorius L.
Anti-ache Activity
Ecd Analysis
Chiral Hplc
Computational Studies on Acetylcholinesterases
期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 8
作者:
Xu, Yechun
;
Cheng, Shanmei
;
Sussman, Joel L.
;
Silman, Israel
;
Jiang, Hualiang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
acetylcholinesterase
computational modeling and simulation
active-site gorge
ligand trafficking
oligomer
catalytic reaction mechanism
Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Cheng, Shanmei
;
Song, Wanling
;
Yuan, Xiaojing
;
Xu, Yechun
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  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C-60 Nanoparticles via in Vitro and in Silico Assays
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 22, 页码: 18626-18638
作者:
Liu, Yanyan
;
Yan, Bing
;
Winkler, David A.
;
Fu, Jianjie
;
Zhang, Aigian
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2018/07/26
C-60 Nanoparticle
Acetylcholinesterase
Competitive Inhibition
Peripheral Anionic Site
Quantitative Nanostructure-activity Relationship
Molecular Docking
Site-directed Mutation
基于高效液相色谱-质谱联用方法筛选天然药用植物中的乙酰胆碱酯酶抑制剂
学位论文
2017, 2016
刘静兰
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2017/06/20
液质联用
乙酰胆碱酯酶抑制剂
在线活性检测
对叶百部
河套大黄
HPLC-MS
Acetylcholinesterase Inhibitors
online activity screening
Stemona tuberosa L
Rheum hotaoense C Y Cheng et Kao
Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review
期刊论文
BIOORGANIC CHEMISTRY, 2017, 卷号: 75, 期号: 12, 页码: 50-61
作者:
Jiang, YY (Jiang, Yingying)
;
Gao, HW (Gao, Hongwei)
;
Turdu, G (Turdu, Gulmira)
;
Gao, HW
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  |  
浏览/下载:18/0
  |  
提交时间:2018/07/20
Alzheimer's Disease
Tcm
Acetylcholinesterase
Inhibitors
Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 127, 期号: 2, 页码: 771-780
作者:
Zhan, GQ (Zhan, Guanqun)
;
Liu, JJ (Liu, Junjun)
;
Zhou, JF (Zhou, Junfei)
;
Sun, B (Sun, Bin)
;
Aisa, HA (Aisa, Haji Akber)
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2017/10/31
Alzheimer's Disease
Ache Inhibitory Activity
Docking Studies
Zephyranthes Candida
Amaryllidaceae Alkaloids
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 133
作者:
Lan, Jin-Shuai
;
Zhang, Tong
;
Liu, Yun
;
Yang, Jing
;
Xie, Sai-Sai
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Donepezil
Benzylpyridinium
Acetylcholinesterase inhibitors antioxidant
beta-Amyloid aggregation
Neuroprotection
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139
作者:
Lan, Jin-Shuai
;
Ding, Yue
;
Liu, Yun
;
Kang, Ping
;
Hou, Jian-Wei
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Monoamine oxidase inhibitors
Acetylcholinesterase inhibitors
Multi-target ligand design
Alzheimer's disease
Coumarin derivatives
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