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浏览/检索结果: 共167条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structural insights into the potency of SK channel positive modulators 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Nam, Young-Woo;  Orfali, Razan;  Liu, Tingting;  Yu, Kunqian;  Cui, Meng 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents 期刊论文 PHARMAZIE, 2017, 卷号: 72, 期号: 12, 页码: 707-713 作者:  Hu, Yuanyuan;  Ruan, Wenchen;  Gao, Anhui;  Zhou, Yubo;  Gao, Lixin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis 期刊论文 JOURNAL OF NATURAL PRODUCTS, 2017, 卷号: 80, 期号: 12, 页码: 3160-3167 作者:  Fan, Yao-Yue;  Xu, Jin-Biao;  Liu, Hong-Chun;  Gan, Li-She;  Ding, Jian 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Design, synthesis and biological evaluation of novel alpha-hederagenin derivatives with anticancer activity 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 427-439 作者:  Liu, Xian-xuan;  Yang, Yan-ting;  Wang, Xiao;  Wang, Kai-yi;  Liu, Jia-qi 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 alpha-Hederagenin derivatives  Synthesis  Apoptosis  Cancer   Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270 作者:  Zhang, Wei-yao;  Lu, Wen-chao;  Jiang, Hao;  Lv, Zheng-bing;  Xie, Yi-qian 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 epigenetics  molecular docking  PRMT1  scaffold hopping  small-molecule inhibitor   Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266 作者:  Zheng, Qiangang;  Tang, Shuai;  Fu, Xianlei;  Chen, Ziqi;  Ye, Yan 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 IDH1 inhibitor  Indane amide  Structure-based rational design   Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336 作者:  Fu, Yan;  Tang, Shuai;  Su, Yi;  Lan, Xiaojing;  Ye, Yan 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Cyclin-dependent kinase  CDK inhibitor  Structure-activity relationship  In vitro and in vivo profiling   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition   Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112 作者:  Ji, Yue-Yang;  Lin, Sen-Dong;  Wang, Yu-Jie;  Su, Ming-Bo;  Zhang, Wei 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Tranylcypromine  LSD1  Stereoselective cyclopropanation  Chiral synthesis  MAO-A  MAO-B   Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187 期刊论文 PHYTOCHEMISTRY LETTERS, 2017, 卷号: 22, 页码: 122-127 作者:  Choochuay, Jutatip;  Xu, Xin;  Rukachaisirikul, Vatcharin;  Guedduaythong, Piyada;  Phongpaichit, Souwalak 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Aspergillus polyporicola  Cytochalasins  Curvularins  Soil-derived fungi  Antimicrobial activity  Cytotoxic activity