Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis

doi:10.1021/acs.jnatprod.7b00412

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis
	Fan, Yao-Yue 2; Xu, Jin-Biao 2; Liu, Hong-Chun2 ; Gan, Li-She 1; Ding, Jian2 ; Yue, Jian-Min2
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-12
卷号	80 期号:12 页码:3160-3167
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00412
文献子类	Article
英文摘要	Ten new cephalotane-type diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated and characterized from Cephalotaxus sinensis. Compounds 1-3 represent the first examples of A-ring-contracted cephalotane-type dinorditerpenoids, and compound 4 is an A-ring-contracted norditerpenoid. The biosynthetic pathways for compounds 1-4 are postulated with the coexisting cephalotane-type troponoids as the precursors. Compounds 11 and 12 showed significant cytotoxicities against a panel of tumor cell lines (A549, KB, HL-60, and HT-29) with IC50 values ranging from 0.464 to 6.093 mu M.
资助项目	National Natural Science Foundation of P. R China[21532007] ; National Natural Science Foundation of P. R China[U1302222] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development"[00000000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020321] ; Chinese Academy of Sciences[CASIMM0120153009]
WOS关键词	NATURAL-PRODUCTS ; FORTUNEI ; ASSAY
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000418879300010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272361]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	1.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Fan, Yao-Yue,Xu, Jin-Biao,Liu, Hong-Chun,et al. Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(12):3160-3167.
APA	Fan, Yao-Yue,Xu, Jin-Biao,Liu, Hong-Chun,Gan, Li-She,Ding, Jian,&Yue, Jian-Min.(2017).Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis.JOURNAL OF NATURAL PRODUCTS,80(12),3160-3167.
MLA	Fan, Yao-Yue,et al."Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis".JOURNAL OF NATURAL PRODUCTS 80.12(2017):3160-3167.