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科研机构
上海药物研究所 [4]
中南大学 [1]
内容类型
期刊论文 [5]
发表日期
2016 [5]
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GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 23, 页码: 5603-5612
作者:
Chen, Cheng
;
Li, He
;
Long, Ya-Qiu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes
FFA1
Biased agonism
SP6616 as a new Kv2.1 channel inhibitor efficiently promotes beta-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways
期刊论文
CELL DEATH & DISEASE, 2016, 卷号: 7
作者:
Zhou, T. T.
;
Quan, L. L.
;
Chen, L. P.
;
Du, T.
;
Sun, K. X.
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Advances in Small-Molecule GPR40 Agonists for Treatment of Type 2 Diabetes Mellitus
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 4, 页码: 736-743
作者:
Li He
;
Long Yaqiu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
type II diabetes mellitus
GPR40
agonists
glucose-stimulated insulin secretion
phenylpropanoic acid
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
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  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
advancesinsmallmoleculegpr40agonistsfortreatmentoftype2diabetesmellitus
期刊论文
chinesejournaloforganicchemistry, 2016, 卷号: 36, 期号: 4, 页码: 736
作者:
Li H(李鹤)
;
Long YQ(龙亚秋)
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
1 FFA1/GPR40 AGONIST
IN-VITRO
DISCOVERY
POTENT
ACIDS
IDENTIFICATION
OPTIMIZATION
CELLS
type II diabetes mellitus
GPR40
agonists
glucose-stimulated insulin secretion
phenylpropanoic acid
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