Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery

doi:10.1007/s12264-022-00959-x

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 先进机器人控制团队

	Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery
	Gao, Zhengrun 8,9; Pang, Zhen 9; Chen, Yiming 9; Lei, Gaowei 9; Zhu, Shuai 9; Li, Guotao 3; Shen, Yundong 7,8,9; Xu, Wendong 1,2,4,5,6,7,8,9
刊名	NEUROSCIENCE BULLETIN
	2022-11-04
页码	19
关键词	Stroke Traumatic brain injury Spinal cord injury Brain-computer interface system Neuroplasticity Ipsilateral motor control Axon regrowth
ISSN号	1673-7067
DOI	10.1007/s12264-022-00959-x
通讯作者	Xu, Wendong(wendongxu@fudan.edu.cn)
英文摘要	Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are leading causes of long-term disability. It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb. Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery. However, the ability to increase plasticity in the injured brain is restricted and difficult to improve. Therefore, over several decades, researchers have been prompted to enhance the compensation by the unaffected hemisphere. Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function. In addition, several clinical treatments have been designed to restore ipsilateral motor control, including brain stimulation, nerve transfer surgery, and brain-computer interface systems. Here, we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.
资助项目	National Natural Science Foundation of China[81902296] ; National Natural Science Foundation of China[82071406] ; National Natural Science Foundation of China[82021002] ; National Natural Science Foundation of China[92168105] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; Shanghai Natural Science Foundation[20XD1420700] ; Shanghai Natural Science Foundation[22ZR1479000]
WOS关键词	CORTICOSPINAL TRACT INJURY ; STEM-CELL TRANSPLANTATION ; CONTRALATERAL C7 TRANSFER ; BRAIN-COMPUTER INTERFACE ; RUBRO-SPINAL TRACT ; FUNCTIONAL RECOVERY ; AXON REGENERATION ; ISCHEMIC-STROKE ; INTRACEREBRAL HEMORRHAGE ; ELECTRICAL-STIMULATION
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000878927000002
资助机构	National Natural Science Foundation of China ; Shanghai Municipal Science and Technology Major Project ; Shanghai Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50675]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_先进机器人控制团队
通讯作者	Xu, Wendong
作者单位	1.Chinese Acad Med Sci, Res Unit Synergist Reconstruct Upper & Lower Limb, Shanghai 200400, Peoples R China 2.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226000, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai 200040, Peoples R China 5.Fudan Univ, State Key Lab Med Neurobiol, Shanghai 200040, Peoples R China 6.Fudan Univ, Inst Brain Sci, Shanghai 200040, Peoples R China 7.Fudan Univ, Jingan Dist Cent Hosp, Dept Hand & Upper Extrem Surg, Shanghai 200040, Peoples R China 8.Fudan Univ, Natl Clin Res Ctr Aging & Med, Shanghai 200040, Peoples R China 9.Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	Gao, Zhengrun,Pang, Zhen,Chen, Yiming,et al. Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery[J]. NEUROSCIENCE BULLETIN,2022:19.
APA	Gao, Zhengrun.,Pang, Zhen.,Chen, Yiming.,Lei, Gaowei.,Zhu, Shuai.,...&Xu, Wendong.(2022).Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.NEUROSCIENCE BULLETIN,19.
MLA	Gao, Zhengrun,et al."Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery".NEUROSCIENCE BULLETIN (2022):19.