Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of   Neural Tube Defects in Offspring

doi:10.1021/es503990v

CORC > 北京大学 > 城市与环境学院

	Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring
	Wang, Bin ; Jin, Lei ; Ren, Aiguo ; Yuan, Yue ; Liu, Jufen ; Li, Zhiwen ; Zhang, Le ; Yi, Deqing ; Wang, Lin-lin ; Zhang, Yali ; Wang, Xilong ; Tao, Shu ; Finnell, Richard H.
刊名	environmental science technology
	2015
关键词	OXIDATIVE STRESS CHILDREN CHINA BIOMARKERS EXPOSURE ASSOCIATION POLLUTANTS COMBUSTION PLACENTA EMISSION
DOI	10.1021/es503990v
英文摘要	Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and have been reported to be a risk factor for human neural tube defects (NTDs). We investigated the relationship between PAH concentrations in maternal serum and NTD risk in offspring using a case-control study design, and explored the link between PAH concentrations to household energy usage characteristics and life styles. One hundred and seventeen women who had NTD-affected pregnancies (cases) and 121 women who delivered healthy infants (controls) were recruited in Northern China. Maternal blood samples were collected at pregnancy termination or at delivery. Twenty-seven PAHs were measured by gas chromatography-mass spectrometry. The concentrations of 13 individual PAHs detected were significantly higher in the cases than in the controls. Clear dose-response relationships between concentrations of most individual PAHs and the risk of total NTDs or subtypes were observed, even when potential covariates were adjusted for. High-molecular-weight PAHs (H-PAHs) showed higher risk than low-molecular-weight PAHs (L-PAHs). No associations between PAH concentrations and indoor life styles and energy usage characteristics were observed. It was concluded that maternal exposure to PAHs was associated with an increased risk of NTDs, and H-PAHs overall posed a higher risk for NTDs than L-PAHs.; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 0; ARTICLE; renag@pku.edu.cn; 1; 588-596; 49
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188743]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Wang, Bin,Jin, Lei,Ren, Aiguo,et al. Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring[J]. environmental science technology,2015.
APA	Wang, Bin.,Jin, Lei.,Ren, Aiguo.,Yuan, Yue.,Liu, Jufen.,...&Finnell, Richard H..(2015).Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring.environmental science technology.
MLA	Wang, Bin,et al."Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring".environmental science technology (2015).