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	Isolation, characterization, and phylogenetic analysis of two new crimean-congo hemorrhagic fever virus strains from the northern region of xinjiang province, china
	Zhang, Yanfang1; Shen, Shu1; Fang, Yaohui1; Liu, Jinliang1; Su, Zhengyuan1; Liang, Jinhao1; Zhang, Zhong1; Wu, Qiaoli1; Wang, Cheng2; Abudurexiti, Abulikemu2
刊名	Virologica sinica
	2018-02-01
卷号	33期号:1页码:74-86
关键词	Crimean-congo hemorrhagic fever virus Mice inoculation Isolate Genotypes Phylogenetic analysis Fukang city Wujiaqu city
ISSN号	1674-0769
DOI	10.1007/s12250-018-0020-7
通讯作者	Zhang, yujiang(xjsyzhang@163.com) ; Deng, fei(df@wh.iov.cn)
英文摘要	Crimean-congo hemorrhagic fever (cchf) caused by the cchf virus (cchfv) is a tick-borne natural focal disease with a mortality rate of approximately 50%. cchfv is widely prevalent in africa, southern asia, the middle east, and southeast europe. cchf outbreaks have been reported previously in xinjiang province, china, especially in its southern region. epidemiological surveys conducted on ticks and animals have revealed the presence of cchfv strains in ticks, rodents, and infected individuals from cities and counties in southern xinjiang. phylogenetic analyses revealed that the chinese cchfv strains belong to one genotype, based on complete sequences of the s segments of its negative-stranded rna genome. the present study reports two new cchfv strains isolated from hyalomma asiaticum asiaticum ticks collected from fukang city and wujiaqu city in the northern region of xinjiang. viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription pcr analyses; these analyses indicated that the genotype of both strains was different from that of other chinese strains. furthermore, previous reports of cchfv in xinjiang were reviewed and phylogenetic analyses were performed. cchfv was found to prevail in fukang city in junggar basin for more than 20 years, and that fukang city and wujiaqu city are considered natural reservoirs of different genotypes of cchfv strains. our findings facilitate the understanding of cchfv distribution in xinjiang province and provide insights into the evolutionary relationships among chinese cchfv strains.
WOS关键词	EPIDEMIOLOGY ; REPLICATION ; RNA
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000428287700007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373325
专题	武汉病毒研究所
通讯作者	Zhang, Yujiang; Deng, Fei
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830002, Xinjiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yanfang,Shen, Shu,Fang, Yaohui,et al. Isolation, characterization, and phylogenetic analysis of two new crimean-congo hemorrhagic fever virus strains from the northern region of xinjiang province, china[J]. Virologica sinica,2018,33(1):74-86.
APA	Zhang, Yanfang.,Shen, Shu.,Fang, Yaohui.,Liu, Jinliang.,Su, Zhengyuan.,...&Deng, Fei.(2018).Isolation, characterization, and phylogenetic analysis of two new crimean-congo hemorrhagic fever virus strains from the northern region of xinjiang province, china.Virologica sinica,33(1),74-86.
MLA	Zhang, Yanfang,et al."Isolation, characterization, and phylogenetic analysis of two new crimean-congo hemorrhagic fever virus strains from the northern region of xinjiang province, china".Virologica sinica 33.1(2018):74-86.

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