Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors

	Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors
	Zhang, Renshuai 1,2; Yu, Rilei 4; Xu, Qi 1,2; Li, Xiangqian 1,2; Luo, Jiao 1,2; Jiang, Bo 1,2; Wang, Lijun 1,2; Guo, Shuju 1,2; Wu, Ning 1,2; Shi, Dayong 1,2,3
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2017-07-07
卷号	134 页码:24-33
关键词	PTP1B Bromophenol Saccharide Selectivity Permeability
英文摘要	Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signaling pathway. Inhibition of PTP1B is expected to improve insulin action. Appropriate selectivity and permeability are the gold standard for excellent PTP1B inhibitors. In this work, molecular hybridization-based screening identified a selective competitive PTP1B inhibitor. Compound 10a has IC50 values of 199 nM against PTP1B, and shows 32-fold selectivity for PTP1B over the closely related phosphatase TCPTP). Molecule docking and molecular dynamics studies reveal the reason of selectivity for PTP1B over TCPTP. Moreover, the cell permeability and cellular activity of compound 10a are demonstrated respectively. (C) 2017 Elsevier Masson SAS. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000401677500003
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/136870]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Renshuai,Yu, Rilei,Xu, Qi,et al. Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017,134:24-33.
APA	Zhang, Renshuai.,Yu, Rilei.,Xu, Qi.,Li, Xiangqian.,Luo, Jiao.,...&Shi, Dayong.(2017).Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,134,24-33.
MLA	Zhang, Renshuai,et al."Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 134(2017):24-33.