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科研机构
上海中医药大学 [6]
厦门大学 [5]
武汉大学 [5]
上海药物研究所 [4]
复旦大学上海医学院 [4]
北京大学 [3]
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期刊论文 [48]
会议论文 [1]
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Liver toxicity of macrolide antibiotics in zebrafish
期刊论文
TOXICOLOGY, 2020, 卷号: 441, 页码: 12
作者:
Zhang, Miao-qing
;
Chen, Bo
;
Zhang, Jing-pu
;
Chen, Ning
;
Liu, Chun-zhao
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/09/22
Liver toxicity
Macrolides
ADMET
RNA-seq analysis
Differentially expressed genes
c-Fos
Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10
作者:
Li, Jun
;
Liu, Gang
;
Ihsan, Awais
;
Yi, Xuejia
;
Wang, Da-Gui
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2019/12/05
Veratrilla baillonii extract
hepatic gene expression
Aconitum brachypodum
liver toxicity
hepatoprotective mechanism
Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats
期刊论文
REPRODUCTIVE TOXICOLOGY, 2019, 卷号: 85
作者:
Guo, Yu
;
Xiao, Di
;
Yang, Xiaojing
;
Zheng, Jiang
;
Hu, Shuwei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
Bioactivation
Cytochrome P450
Pulmonary toxicities
Liver injury/toxicity
Reactive metabolites/intermediates
Parental exposure to 2,2 ',4,4 ' 5-pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 372, 页码: 11-18
作者:
Wu, Luyin[1]
;
Li, Yunfeng[2]
;
Ru, Huijun[3]
;
Xie, Huaxiao[4]
;
Yao, Fan[5]
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/01/02
PBDEs
Zebrafish
Developmental toxicity
Thyroid disruption
Hypothalamic-pituitary-thyroid-liver (HPTL) axis
Metabolomics Reveals Metabolic Changes Caused by Low-Dose 4-Tert-Octylphenol in Mice Liver
期刊论文
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 卷号: 15, 期号: 12
作者:
Zhou, Kun
;
Ding, Xingwang
;
Yang, Jing
;
Hu, Yanhui
;
Song, Yun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
metabolomics
4-tert-octylphenol
low-dose
liver toxicity
Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice
期刊论文
TOXICOLOGY, 2018, 卷号: 408
作者:
Wang, Guihua
;
He, Bo
;
Hu, Wen
;
Liu, Kexin
;
Gong, Xiaohan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Prenatal methimazole exposure
Fetal liver developmental toxicity
Insulin-like growth factor 1 (IGF1)
Glucose and lipid metabolic function
Effects of Acute Copper Exposure on Physiological and Cytological Responses in Liver of GIFT Tilapia (Oreochromis niloticus)
期刊论文
ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH, 2018, 卷号: 70
作者:
Yu, Deng-Hang
;
Chang, Jia-Zhi
;
Dong, Gui-Fang
;
Liu, Jun*
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/27
copper toxicity
GIFT tilapia
ultrastructure of liver
lipid metabolism
Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles
期刊论文
Journal of Environmental Sciences, 2018, 卷号: 69
作者:
Wang Xue
;
Cheng Wenge
;
Yang Qiuyuan
;
Niu Hongyun
;
Liu Qian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/11/23
F-19 MAGNETIC-RESONANCE
GRAPHENE OXIDE
PERFLUOROOCTANE SULFONATE
IN-VITRO
CELLS
TOXICITY
DAMAGE
LIVER
METABOLISM
MECHANISMS
Fluorinated nanoparticles
Polymer
Cytotoxicity
Oxidative stress
Health risk
Lanthanum exerts acute toxicity and histopathological changes in gill and liver tissue of rare minnow (Gobiocypris rarus)
期刊论文
ECOTOXICOLOGY, 2017, 卷号: 26, 期号: 9, 页码: 1207-1215
作者:
Hua, Dong
;
Wang, Jianwei
;
Yu, Denghang
;
Liu, Jun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/07/03
Toxicity
Gobiocypris rarus
La(III)
Histopathological
Gill
Liver
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