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中国医学科学院 北... [12]
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期刊论文 [53]
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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
MiRNA-204-5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 卷号: 566
作者:
Ding, Meng
;
Yang, Hailing
;
Liu, Yang
;
Qiu, Yunfeng
;
Zhang, Ying
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Oxaliplatin
miRNA-204-5p
Colon cancer
Mesoporous silica nanoparticles
Antitumor efficacy
2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 705-714
作者:
Zhuo, Lin-Sheng
;
Xu, Hong-Chuang
;
Wang, Ming-Shu
;
Zhao, Xing-E
;
Ming, Zhi-Hui
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
2,7-Naphthyridone
Antitumor
In vivo efficacy
MET kinase inhibitor
Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy
期刊论文
2019, 卷号: 134, 页码: 178-184
作者:
Guo, Yifei
;
Wang, Ting
;
Qiu, Hanhong
;
Han, Meihua
;
Dong, Zhengqi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
Influence of architecture
Steric hindrance
HCPT nanoparticles
Antitumor efficacy
Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations
期刊论文
DRUG DELIVERY, 2018, 卷号: 25, 期号: 1, 页码: 166-177
作者:
Zhang, Zongrui
;
Wang, Xinyu*
;
Li, Binbin
;
Hou, Yuanjing
;
Yang, Jing
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/04
Paclitaxel
morphological features
sustained release
antitumor efficacy
cancer therapy
The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer.
期刊论文
Biomedecine & pharmacotherapie, 2018, 卷号: 108, 页码: 184-193
作者:
Yuan Lu
;
Zhang Siruo
;
Li Huan
;
Yang Fan
;
Mushtaq Noosheen
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/11/26
5-Fluorouracil
16S rRNA gene
Antibiotics
Probiotics
Antitumor efficacy
Gut flora
GOLPH2-regulated oncolytic adenovirus, GD55, exerts strong killing effect on human prostate cancer stem-like cells in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 3, 页码: 405-414
作者:
Ying, Chang
;
Xiao, Bo-duan
;
Qin, Yun
;
Wang, Bin-rong
;
Liu, Xin-yuan
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/04/28
Potent Antitumor-activity
Colorectal-cancer
Gene
Identification
Heterogeneity
Plasticity
Resistance
Xenograft
Promoter
Efficacy
Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 503, 期号: 4, 页码: 2758-2763
作者:
Xie, Wenjie
;
Hao, Jiali
;
Liu, Xinyuan
;
Zhang, Kangjian
;
Liu, Xinyuan
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/04/28
Oncolytic Adenovirus
Cancer Virotherapy
Antitumor Efficacy
Gastric-cancer
Lung-cancer
Therapy
Potency
Protein
Combination of Oxaliplatin and Vit.E-TPGS in Lipid Nanosystem for Enhanced Therapeutic Efficacy in Colon Cancers
期刊论文
PHARMACEUTICAL RESEARCH, 2018, 卷号: 35, 期号: 2
作者:
Wang, Yanlei
;
Zhang, Xiang
;
Zhang, Wenqiang
;
Dong, Hao
;
Zhang, Wenjie
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
antitumor efficacy
apoptosis
colon cancer
nanoparticles
oxaliplatin
An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor effects against melanoma
期刊论文
2018, 卷号: 51, 期号: 11, 页码: 572-577
作者:
Wei, Mulan
;
Liu, Xujie
;
Cao, Chunyu
;
Yang, Jianlin
;
Lv, Yafeng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/01/03
Antitumor efficacy
Melanoma
MMP-2/9
PD-1/PD-L1
Targeting protein
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