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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [9]
发表日期
2021 [3]
2020 [2]
2019 [2]
2018 [2]
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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8644-8665
作者:
Kong, Qidi
;
Pan, Wei
;
Xu, Heng
;
Xue, Yaru
;
Guo, Bin
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-beta RI/Smad Signaling
期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 6, 页码: 19
作者:
Luo, Xin
;
Deng, Qiangqiang
;
Xue, Yaru
;
Zhang, Tianwei
;
Wu, Zhitao
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
pulmonary fibrosis
bleomycin
magnesium lithospermate B
transforming growth factor-beta
Smad signaling
Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway
期刊论文
SCIENTIFIC REPORTS, 2020, 卷号: 10, 期号: 1, 页码: 13
作者:
Xue, Yaru
;
Deng, Qiangqiang
;
Zhang, Qingli
;
Ma, Zhenghua
;
Chen, Binfan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:
Wang, Ying
;
Zhu, Yao
;
Niu, Junxing
;
Deng, Qiangqiang
;
Guo, Shimeng
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2020/12/21
Bile acid analog
NASH
TGR5
Cd36
AMPK alpha
The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/Reperfusion via Inhibiting the Jak2/Stat3 Signaling Pathway
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 13
作者:
Zhang, Ning
;
Han, Li
;
Xue, Yaru
;
Deng, Qiangqiang
;
Wu, Zhitao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
magnesium lithospermate B
hepatic ischemia/reperfusion
acute injury
anti-inflammation
Jak2/Stat3 signaling pathway
Intestinal Transporter-Associated Drug Absorption and Toxicity
期刊论文
DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 卷号: 1141, 页码: 361-405
作者:
Xue, Yaru
;
Ma, Chenhui
;
Hanna, Imad
;
Pan, Guoyu
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Intestinal transporter
Drug absorption
Bile acid transport
BDDCS
Drug-induced toxicity
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine
期刊论文
XENOBIOTICA, 2018, 卷号: 48, 期号: 3, 页码: 314-323
作者:
Xiao, Ling
;
Xue, Yaru
;
Zhang, Cuifeng
;
Wang, Le
;
Lin, Yunfei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Berberine
MATE1
hepatobiliary distribution
excretion
DDIs
metabolismpharmacokineticsandhepaticdispositionofxanthonesandsaponinsonzhimutreatmentsforexplorativelyinterpretingthediscrepancybetweentheherbalsafetyandtimosaponina3inducedhepatotoxicity
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 12, 页码: 1923
作者:
Xie Yang
;
Zhou Xu
;
Pei Hu
;
Chen Mingcang
;
Sun Zhaolin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
B-II
LIVER-INJURY
IN-VITRO
ANEMARRHENA-ASPHODELOIDES
OXIDATIVE STRESS
RAT PLASMA
A-III
MANGIFERIN
NORATHYRIOL
EXTRACT
Zhimu
timosaponin A3
mangiferin
pharmacokinetics
metabolism
hepatotoxicity
antioxidant
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