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科研机构
上海药物研究所 [96]
内容类型
期刊论文 [95]
会议论文 [1]
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2021 [8]
2020 [4]
2019 [5]
2018 [8]
2017 [6]
2016 [7]
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Chemistry [1]
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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Combating liver cancer through GO-targeted biomaterials
期刊论文
BIOMEDICAL MATERIALS, 2021, 卷号: 16, 期号: 6, 页码: 14
作者:
Huang, Xing
;
Zhang, Jiaxin
;
Song, Yijie
;
Zhang, Tong
;
Wang, Bing
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/11/04
graphene oxide
hydroxycamptothecin
anti-cancer
drug delivery system
targeting
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2021, 页码: 7
作者:
Lin, Feifei
;
Pan, Anni
;
Ye, Yang
;
Liu, Jia
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  |  
浏览/下载:30/0
  |  
提交时间:2021/08/17
LC-MS
MS
monocrotaline
monocrotaline N-oxide
pharmacokinetics
Honokiol: A naturally occurring lignan with pleiotropic bioactivities
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 卷号: 19, 期号: 7, 页码: 481-490
作者:
Chen Cheng
;
Zhang Qing-Wen
;
Ye Yang
;
Lin Li-Gen
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  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
Honokiol
Natural sources
Ethnopharmacological uses
Physicochemical properties
Bioactivities
Clinical trials
Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/06/11
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans
期刊论文
ARCHIVES OF TOXICOLOGY, 2020, 页码: 7
作者:
Ma, Jiang
;
Zhang, Wei
;
He, Yisheng
;
Zhu, Lin
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/12/24
Pyrrolizidine alkaloids
Liver injury
Diagnostic biomarkers
Pyrrole-hemoglobin adducts
Pyrrole-plasma protein adducts
Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice
期刊论文
TOXICOLOGY LETTERS, 2020, 卷号: 333, 页码: 290-302
作者:
Zhao, Jie
;
Xie, Cen
;
Wang, Kanglong
;
Takahashi, Shogo
;
Krausz, Kristopher W.
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/12/21
Triptolide
Transcriptomics
Metabolomics
Apoptosis
Acylcarnitine
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