CORC

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CORC

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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang
收藏  |  浏览/下载：58/0  |  提交时间：2022/01/18
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:  Zou, Hui-xi;  Zhang, Yu-feng;  Zhong, Da-fang;  Jiang, Yong;  Liu, Fei
收藏  |  浏览/下载：17/0  |  提交时间：2022/01/04
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:  Meng, Jian;  Zhang, Hua;  Bao, Jing-jing;  Chen, Zhen-dong;  Liu, Xiao-yun
收藏  |  浏览/下载：69/0  |  提交时间：2021/06/11
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:  Meng, Jian;  Zhang, Hua;  Bao, Jing-jing;  Chen, Zhen-dong;  Liu, Xiao-yun
收藏  |  浏览/下载：70/0  |  提交时间：2021/06/11
Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells 期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:  Zhang, Mi;  Quan, Haitian;  Fu, Li;  Li, Yun;  Fu, Haoyu
收藏  |  浏览/下载：18/0  |  提交时间：2021/05/24
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers 期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:  Zhu, Yun-ting;  Zhang, Yi-fan;  Jiang, Jin-fang;  Yang, Yong;  Guo, Li-xia
收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 16, 页码: 6
作者:  Su, Zhicheng;  Yang, Tingyuan;  Wang, Jie;  Lai, Mengzhen;  Tong, Linjiang
收藏  |  浏览/下载：27/0  |  提交时间：2020/12/24
EGFR  NSCLC  C797S  
Integrative Proteomic Characterization of Human Lung Adenocarcinoma 期刊论文
CELL, 2020, 卷号: 182, 期号: 1, 页码: 245-+
作者:  Xu, Jun-Yu;  Zhang, Chunchao;  Wang, Xiang;  Zhai, Linhui;  Ma, Yiming
收藏  |  浏览/下载：48/0  |  提交时间：2020/12/24
Safety, Clinical Activity, and Pharmacokinetics of Al flutinib (AST2818) in Patients With Advanced NSCLC With EGFR T790M Mutation 期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2020, 卷号: 15, 期号: 6, 页码: 1015-1026
作者:  Shi, Yuankai;  Zhang, Shucai;  Hu, Xingsheng;  Feng, Jifeng;  Ma, Zhiyong
收藏  |  浏览/下载：36/0  |  提交时间：2020/12/24
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01

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