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科研机构
上海药物研究所 [64]
内容类型
期刊论文 [62]
会议论文 [2]
发表日期
2021 [5]
2020 [5]
2019 [8]
2018 [10]
2017 [7]
2016 [7]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy
期刊论文
CHEMICAL SCIENCE, 2021, 页码: 9
作者:
Dou, Wei-Tao
;
Xu, Fugui
;
Xu, Chen-Xi
;
Gao, Jie
;
Ru, Hong-Bo
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/08/17
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 卷号: 119, 页码: 12
作者:
Xu, Xiaoding
;
Dong, Yunxia
;
Ma, Ningning
;
Kong, Weiwen
;
Yu, Chuwei
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/08/17
miR-337-3p
PCSK9
LDL-C
Hyperlipidemia
Dual regulation
The ups, downs and new trends of IDO1 inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 12
作者:
Chen, Shulun
;
Tan, Jing
;
Zhang, Ao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/08/17
Immunotherapy
Cancer
Indoleamine 2,3-dioxygenase
Tryptophan 2,3-dioxygenase
Inhibitors
Checkpoint Inhibitor
A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 1, 页码: 283-299
作者:
Li, Jinyang
;
Lu, Jiasheng
;
Guo, Haiyan
;
Zhou, Jianfen
;
Wang, Songli
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Liposome
mn
c(RGDyK)
Immune opsonization
Immunogenicity
Anti-glioma efficacy
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery
期刊论文
BIOMATERIALS, 2020, 卷号: 255, 页码: 12
作者:
Chen, Binfan
;
Gao, Ang
;
Tu, Bin
;
Wang, Yonghui
;
Yu, Xiaolu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
Tumor-associated macrophage
Glycolysis
mTOR
Angiogenesis
Tumor immune microenvironment
Liposome
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Hao, Bing-bing
;
Li, Xiao-jing
;
Jia, Xing-long
;
Wang, Yu-xing
;
Zhai, Lin-hui
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
immunomodulatory drugs (IMiDs)
CC-885
BNIP3L
mitophagy
CRBN
acute myeloid leukemia
mitochondria-targeting drugs
MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability
期刊论文
ONCOGENE, 2020, 页码: 16
作者:
Li, Yu
;
Zhang, Huibiao
;
Fan, Lei
;
Mou, Jiahui
;
Yin, Yue
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFR(T790M) mutation
期刊论文
THERANOSTICS, 2020, 卷号: 10, 期号: 14, 页码: 6122-6135
作者:
Yin, Weimin
;
Zhao, Yuge
;
Kang, Xuejia
;
Zhao, Pengfei
;
Zhao, Xuhong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
brain targeting delivery
tumor-associated macrophage
non-small cell lung cancer (NSCLC)
drug resistance
tyrosine kinase inhibitors (TKI)
EGFR T790M mutation
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