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浏览/检索结果: 共67条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位    发表日期：2017     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654 作者:  Li, Jing-qiu;  Wu, Xian;  Gan, Lu;  Yang, Xiang-liang;  Miao, Ze-hong 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 hepatocellular carcinoma  hypoxia  5-fluorouracil  sorafenib  drug resistance   An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance 期刊论文 CHEMICAL SCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 8012-8018 作者:  Jiang, Yuejing;  Cheng, Juan;  Yang, Chengyu;  Hu, Yongzhou;  Li, Jia 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat 期刊论文 NANO LETTERS, 2017, 卷号: 17, 期号: 12, 页码: 7684-7690 作者:  Peng, Huige;  Chen, Binfan;  Huang, Wei;  Tang, Yubo;  Jiang, Yifan 收藏  |  浏览/下载：65/0  |  提交时间：2019/01/08 Tumor-associated macrophages  gefitinib  vorinostat  EGFR(T790M)  nonsmall cell lung cancer  drug resistance   Mutation L1196M-induced conformational changes and the drug resistant mechanism of anaplastic lymphoma kinase studied by free energy perturbation and umbrella sampling 期刊论文 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 卷号: 19, 期号: 44, 页码: 30239-30248 作者:  Chen, Jianzhong;  Wang, Jinan;  Zhu, Weiliang 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy 期刊论文 ADVANCED FUNCTIONAL MATERIALS, 2017, 卷号: 27, 期号: 44 作者:  Zhao, Pengfei;  Yin, Weimin;  Wu, Aihua;  Tang, Yisi;  Wang, Jinyu 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 albumin nanoparticles  combination therapy  mannose receptors  multidrug resistance  SPARC   Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors 期刊论文 FRONTIERS IN CHEMISTRY, 2017, 卷号: 5 作者:  Hu, Xiuqin;  Wang, Disha;  Tong, Yi;  Tong, Linjiang;  Wang, Xia 收藏  |  浏览/下载：60/0  |  提交时间：2019/01/08 EGFR  tyrosine kinase inhibitors  anilinopyrtmidine  glycosides  carbohydrate-based drugs   Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527 作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang 收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08 Epidermal growth factor receptor  Tyrosine kinase inhibitors  Non-small cell lung cancer  T790M  Mutant-selective   Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review 期刊论文 MARINE DRUGS, 2017, 卷号: 15, 期号: 11 作者:  Shah, Sayed Asmat Ali;  Akhter, Najeeb;  Auckloo, Bibi Nazia;  Khan, Ishrat;  Lu, Yanbin 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 cyanobacteria  secondary metabolites  biological properties and applications