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浏览/检索结果: 共133条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 24, 页码: 10231-10244 作者:  Liu, Qiufeng;  Huang, Fubao;  Yuan, Xiaojing;  Wang, Kai;  Zou, Yi 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Miao, Chunxiao;  Lv, Yuanyuan;  Zhang, Wanli;  Chai, Xiaoping;  Feng, Lixing 收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 cancer cachexia  PDTC  C2C12 myotubes  3T3-L1 adipocytes  muscle atrophy  fat lipolysis   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents 期刊论文 PHARMAZIE, 2017, 卷号: 72, 期号: 12, 页码: 707-713 作者:  Hu, Yuanyuan;  Ruan, Wenchen;  Gao, Anhui;  Zhou, Yubo;  Gao, Lixin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 Design, synthesis and biological evaluation of novel alpha-hederagenin derivatives with anticancer activity 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 427-439 作者:  Liu, Xian-xuan;  Yang, Yan-ting;  Wang, Xiao;  Wang, Kai-yi;  Liu, Jia-qi 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 alpha-Hederagenin derivatives  Synthesis  Apoptosis  Cancer   Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1655-1662 作者:  Dong, Xin-yue;  Lang, Tian-qun;  Yin, Qi;  Zhang, Peng-cheng;  Li, Ya-ping 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 pH-sensitive polymer  co-delivery  micelle  docetaxel  silibinin  breast cancer  mouse breast cancer cell line 4T1  metastasis   Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133 作者:  Jin, Jiyu;  Huang, Suling;  Wang, Lei;  Leng, Ying;  Lu, Wei 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 adipose triglyceride lipase inhibitors  Atglistatin  structure-activity relationship  thiourea   Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride 期刊论文 JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 106, 期号: 12, 页码: 3548-3555 作者:  Gui, Zhiping;  Wu, Xingxing;  Wang, Shuyan;  Cao, Yingji;  Wan, Jun 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 microarray  transdermal drug delivery  skin  permeability  pharmacokinetics  biocompatibility   Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336 作者:  Fu, Yan;  Tang, Shuai;  Su, Yi;  Lan, Xiaojing;  Ye, Yan 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Cyclin-dependent kinase  CDK inhibitor  Structure-activity relationship  In vitro and in vivo profiling   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition