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Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer
期刊论文
PEERJ, 2022, 卷号: 10
作者:
Zhu, Lina
;
Zhao, Hongxin
;
Wang, Yizhuo
;
Yu, Chuandi
;
Liu, Juanjuan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/12/23
GPCR
Dissociation constant
Detergents
Styrene maleic acid copolymer nanodiscs
Smoothened receptors
NMR
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12
作者:
Zhang, Hui
;
Chen, Kun
;
Tan, Qiuxiang
;
Shao, Qiang
;
Han, Shuo
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  |  
浏览/下载:44/0
  |  
提交时间:2021/08/17
Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118
作者:
Zhou, Xiaoting
;
Gao, Yan
;
Wang, Weiwei
;
Yang, Xiaolin
;
Yang, Xiuna
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/06/15
succinate dehydrogenase
Mycobacterium smegmatis
electron transport chain
cryoelectron microscopy
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Mechanically Regulated Outside-In Activation of an I-Domain-Containing Integrin
期刊论文
BIOPHYSICAL JOURNAL, 2020, 卷号: 119, 期号: 5, 页码: 966-977
作者:
Mao DB(毛德斌)
;
Lv SQ(吕守芹)
;
Zhang X(张潇)
;
Long M(龙勉)
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  |  
浏览/下载:25/0
  |  
提交时间:2020/10/29
Revealing the Positive Binding Cooperativity Mechanism between the Orthosteric and the Allosteric Antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 628-637
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Hongli
;
Zhang, Qianqian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/01/18
CC chemokine receptor 2
orthosteric antagonist
allosteric antagonist
binding cooperativity
metadynamics simulation
Gaussian accelerated MD simulation
Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989
作者:
Zhou, Fang
;
Ding, Kang
;
Zhou, Yiqing
;
Liu, Yang
;
Liu, Xiaoyan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
;
Shi, Danfeng
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/11/10
kappa-opioid receptor
Gaussian accelerated molecular dynamics simulation
agonist
antagonist
conformational change
Crystal structure of the Frizzled 4 receptor in a ligand-free state
期刊论文
NATURE, 2018, 卷号: 560, 期号: 7720, 页码: 666-+
作者:
Yang, Shifan
;
Wu, Yiran
;
Xu, Ting-Hai
;
de Waal, Parker W.
;
He, Yuanzheng
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2019/01/08
Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side
期刊论文
BIOCHEMISTRY, 2018, 卷号: 57, 期号: 32, 页码: 4767-4775
作者:
Zhang, Qiansen
;
Zhou, Mang
;
Zhao, Lifen
;
Jiang, Hualiang
;
Yang, Huaiyu
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
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