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科研机构
上海药物研究所 [17]
山东大学 [3]
大连化学物理研究所 [1]
上海大学 [1]
复旦大学上海医学院 [1]
生态环境研究中心 [1]
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期刊论文 [24]
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Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16
作者:
Yuliantie, Elita
;
van der Velden, Wijnand J. C.
;
Labroska, Viktorija
;
Dai, Antao
;
Zhao, Fenghui
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
Glucose-dependent insulinotropic polypeptide receptor
G protein-coupled receptor
GPCR structure-function relationship
ERK
cAMP
Arrestin
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8
作者:
Wang, Yu-zhe
;
Yang, De-hua
;
Wang, Ming-wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
glucagon-like peptide-1 receptor
glucose-dependent insulinotropic peptide receptor
peptide 19
LY3298176
heteromerization
type 2 diabetes
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 13
作者:
Yuliantie, Elita
;
Darbalaei, Sanaz
;
Dai, Antao
;
Zhao, Peishen
;
Yang, Dehua
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
Glucose-dependent insulinotropic peptide receptor
Glucagon-like peptide-1 receptor
Biased agonist
GPCR signaling
A Designed alpha-GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d-iNKT Axis and CD11b-Positive Monocytes/Macrophages
期刊论文
ADVANCED SCIENCE, 2020, 卷号: 7, 期号: 14, 页码: 1-9
作者:
Ma, Juan
;
He, Peng
;
Zhao, Chuanfang
;
Ren, Quanzhong
;
Dong, Zheng
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/09/14
antitumor activity
CD11b monocytes
CD1d
Th1-biased immune responses
alpha-GalCer analogs
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Activation of the GLP-1 receptor by a non-peptidic agonist
期刊论文
NATURE, 2020, 页码: 432-+
作者:
Zhao, Peishen
;
Liang, Yi-Lynn
;
Belousoff, Matthew J.
;
Deganutti, Giuseppe
;
Fletcher, Madeleine M.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Synthesis and evaluation of novel biased µ-opioid-receptor (µOR) agonists
期刊论文
Molecules, 2019, 卷号: 24, 期号: 2
作者:
Ma M.
;
Sun J.
;
Li M.
;
Yu Z.
;
Cheng J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Gi signaling pathway
PZM21
Structure–activity relationship
β-arrestin-2 recruitment
µOR-biased agonist
Synthesis and Evaluation of Novel Biased -Opioid-Receptor (OR) Agonists
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Ma, Mengjun
;
Sun, Jialin
;
Li, Menghua
;
Yu, Zixing
;
Cheng, Jingchao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
OR-biased agonist
PZM21
Gi signaling pathway
beta-arrestin-2
recruitment
structure-activity relationship
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