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科研机构
上海药物研究所 [33]
内容类型
期刊论文 [33]
发表日期
2021 [4]
2020 [1]
2019 [1]
2018 [1]
2017 [2]
2016 [2]
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Structural insights into ligand recognition and activation of the melanocortin-4 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 13
作者:
Zhang, Huibing
;
Chen, Li-Nan
;
Yang, Dehua
;
Mao, Chunyou
;
Shen, Qingya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and beta-d-N-4-hydroxycytidine
期刊论文
VIROLOGICA SINICA, 2021, 页码: 9
作者:
Xie, Yuanchao
;
Guo, Xiaozhen
;
Hu, Tianwen
;
Wei, Daibao
;
Ma, Xiuli
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Porcine epidemic diarrhea virus (PEDV)
Nucleoside analog
RNA dependent RNA polymerase (RdRp)
Antiviral activity
What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design
期刊论文
MEDICINAL RESEARCH REVIEWS, 2021, 页码: 34
作者:
Xiong, Muya
;
Su, Haixia
;
Zhao, Wenfeng
;
Xie, Hang
;
Shao, Qiang
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
3C-like protease
binding modes
coronavirus
inhibitors
structure and function
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 9
作者:
Gu, Dongyan
;
Cheng, Gang
;
Zhang, Mengmeng
;
Zhou, Yu-Bo
;
Li, Jia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/05/24
PI3K alpha inhibitors
Virtual screening
2-(5-(quinolin-6-yl)-1,3,4 oxadiazol-2-yl)acetamide
Molecular dynamics
Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes
期刊论文
GUT MICROBES, 2020, 卷号: 11, 期号: 5, 页码: 1348-1361
作者:
Li, Leyuan
;
Chang, Lu
;
Zhang, Xu
;
Ning, Zhibin
;
Mayne, Janice
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
Gut microbiome
functionality
butyrate
Akkermansia
berberine
metaproteomics
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
作者:
Tao, Hongru
;
Wang, Jun
;
Lu, Wenchao
;
Zhang, Rukang
;
Xie, Yiqian
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9, 页码: 1544-1552
作者:
Lu, Tian
;
Hu, Jun-chi
;
Lu, Wen-chao
;
Han, Jie
;
Ding, Hong
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
AlphaScreen
high-throughput screening
SMARCA2
bromodomain
small molecule inhibitor
Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 13, 页码: 3315-3329
作者:
Chen, Liu
;
Chen, Danqi
;
Tang, Le
;
Ren, Jing
;
Chen, Jiaojiao
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Phosphodiesterase
PDE10A
Purine
Inhibitor
Anti-psychotic
Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist RevealsMechanisms of Chemokine Recognition and Molecular Mimicry by HIV
期刊论文
IMMUNITY, 2017, 卷号: 46, 期号: 6, 页码: 1005-+
作者:
Zheng, Yi
;
Han, Gye Won
;
Abagyan, Ruben
;
Wu, Beili
;
Stevens, Raymond C.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Inhibitory efficacy of bufadienolides on Na,K-pump activity versus cell proliferation
期刊论文
Biochemistry and biophysics reports, 2016, 卷号: 6, 页码: 158-164
作者:
Xu, Yinfang
;
Liu, Xuan
;
Schwarz, Silvia
;
Hu, Lihong
;
Guo, Dean
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
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