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科研机构
海洋研究所 [24]
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期刊论文 [19]
专利 [5]
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2020 [3]
2019 [3]
2018 [1]
2017 [2]
2016 [1]
2013 [3]
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Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:
Luo, Jiao
;
Zheng, Meiling
;
Jiang, Bo
;
Li, Chao
;
Guo, Shuju
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2020/09/29
bromophenol
PTP1B inhibitor
selectivity
cell permeability
oral bioavailability
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study
期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:
Li, Xiuxue
;
Wang, Lijun
;
Jia, Xiaoling
;
Guo, Chuanlong
;
Li, Chao
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/09/23
Novel compound
Quantitation
UHPLC-TOF-MS
Pharmacokinetics
The Characteristics of Storm Wave Behavior and Its Effect on Cage Culture Using the ADCIRC plus SWAN Model in Houshui Bay, China
期刊论文
JOURNAL OF OCEAN UNIVERSITY OF CHINA, 2020, 卷号: 19, 期号: 2, 页码: 307-319
作者:
Yin, Chao
;
Huang, Haijun
;
Wang, Daoru
;
Liu, Yanxia
;
Guo, Ziyue
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/09/21
storm wave
ADCIRC plus SWAN
maximum significant wave height
Houshui Bay
deep sea net-cage
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
作者:
Xu, Qi
;
Wu, Ning
;
Li, Xiangqian
;
Guo, Chuanlong
;
Li, Chao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:
Wang, Lijun
;
Guo, Chuanlong
;
Li, Xiuxue
;
Yu, Xuemin
;
Li, Xiangqian
收藏
  |  
浏览/下载:184/0
  |  
提交时间:2019/08/29
Bromophenol-thiazolylhydrazone hybrids
Synthesis
Multifunctional agents
eIF4E/eIF4G interaction
Autophagy
ROS
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice
期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
作者:
Li, Chao
;
Luo, Jiao
;
Guo, Shuju
;
Jia, Xiaoling
;
Guo, Chuanlong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/08/28
type 2 diabetes mellitus
protein tyrosine phosphatase 1B
insulin resistance
hypoglycemic activity
dyslipidemia
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:
Li, Ning
;
Wang, Li-Jun
;
Jiang, Bo
;
Guo, Shu-Ju
;
Li, Xiang-Qian
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/08/21
Pyrimidinedionederivatives
DPP-4 inhibitor
Molecular hybrid
SARs
Type 2 diabetes
The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
期刊论文
GIGASCIENCE, 2017, 卷号: 6, 期号: 8
作者:
Du, Xiaodong
;
Fan, Guangyi
;
Jiao, Yu
;
Zhang, He
;
Guo, Ximing
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2018/01/11
Genome
Biomineralization
Nacre
Vwa-containing Protein
Pinctada Fucata Martensii
Development of a new deep-sea hybrid Raman insertion probe and its application to the geochemistry of hydrothermal vent and cold seep fluids
期刊论文
DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS, 2017, 卷号: 123, 页码: 1-12
作者:
Zhang, Xin
;
Du, Zengfeng
;
Zheng, Ronger
;
Luan, Zhendong
;
Qi, Fujun
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2017/09/30
Hydrothermal Vent
Cold Seep
Raman Spectroscopy
Geochemistry
In Situ Analysis
Deep Sea
Interactions of the Greater Ontong Java mantle plume component with the Osbourn Trough
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Zhang, Guo-Liang
;
Li, Chao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2017/03/21
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