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科研机构
上海药物研究所 [10]
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期刊论文 [10]
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2021 [1]
2020 [1]
2019 [1]
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A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
收藏
  |  
浏览/下载:149/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Structural basis of ligand recognition and self-activation of orphan GPR52
期刊论文
NATURE, 2020, 页码: 21
作者:
Lin, Xi
;
Li, Mingyue
;
Wang, Niandong
;
Wu, Yiran
;
Luo, Zhipu
收藏
  |  
浏览/下载:176/0
  |  
提交时间:2020/07/01
Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2019, 页码: 6
作者:
Cheng, Cheng
;
Li, Ying-Xian
;
Zhang, Ji-Quan
;
Zhao, Yong-Long
;
Zhang, Lin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Isoquinoline-1,3(2H,4H)-dione
Amination reaction
Asymmetric catalysis
Bifunctional catalyst
The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 10, 页码: 1943-1948
作者:
Zhang, Wen-Ming
;
Yao, Yang
;
Yang, Teng
;
Wang, Xue-Ying
;
Zhu, Zhen-Yun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Antistaphylococcal
Multidrug-resistant
Synthesis
Oxime
Dehydroabietic acid
The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 127, 页码: 917-927
作者:
Zhang, Wen-Ming
;
Yang, Teng
;
Pan, Xue-Ying
;
Liu, Xin-Lan
;
Lin, Hai-Xia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Antistaphylococcal
Muitidrug-resistant
Synthesis
Oxime
Dehydroabietic acid
Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 124, 页码: 981-991
作者:
Ma, Guang-Hui
;
Ye, Yan
;
Zhang, Dan
;
Xu, Xin
;
Si, Pei
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
HFMD
EV71 3C(Pro)
Non-peptidyl inhibitor
Virtual screening
Nuclear-targeting TAT-PEG-Asp(8)-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 8, 页码: 1110-1120
作者:
Pan, Zhen-zhen
;
Wang, Hui-yuan
;
Zhang, Meng
;
Lin, Ting-ting
;
Zhang, Wen-yuan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
doxorubicin
multidrug resistance
cell-penetrating peptide
poly(aspartic acid)
intranuclear delivery
nanoparticles
human colon cancer HCT8/ADR cells
Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders
期刊论文
ACS medicinal chemistry letters, 2016, 卷号: 7, 期号: 4, 页码: 397-402
作者:
Xu, Heng
;
Lu, Hongfu
;
Xu, Zhongmiao
;
Luan, Linbo
;
Li, Chengyong
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Nuclear-targeting TAT-PEG-Asp_8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer
期刊论文
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 8, 页码: 1110
作者:
Pan Zhenzhen
;
Wang Huiyuan
;
Zhang Meng
;
Lin Tingting
;
Zhang Wenyuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
MESOPOROUS SILICA NANOPARTICLES
CELL PENETRATING PEPTIDES
MULTIDRUG-RESISTANCE
P-GLYCOPROTEIN
PLGA NANOPARTICLES
COLORECTAL-CANCER
BREAST-CANCER
DELIVERY
CHEMOTHERAPY
INHIBITION
doxorubicin
multidrug resistance
cell-penetrating peptide
poly(aspartic acid)
intranuclear delivery
nanoparticles
human colon cancer HCT8/ADR cells
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9, 页码: 1149-1155
作者:
Fang, Xing
;
Guo, Lin
;
Jia, Jia
;
Jin, Guo-zhang
;
Zhao, Bin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
SKF83959
monoamine transporter
serotonin
norepinephrine
dopamine
depression
DOV21947
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