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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
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2021 [3]
2020 [1]
2018 [2]
2017 [2]
2014 [2]
2013 [1]
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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020)
期刊论文
MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
Molecular Cancer, 2021, 卷号: 20, 期号: 1
作者:
Zhang,Tao
;
Qu,Rong
;
Chan,Shingpan
;
Lai,Mengzhen
;
Tong,Linjiang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer (NSCLC)
EGFR T790M
Small-molecule inhibitor
Drug resistance
Ack1
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027
作者:
Gu, Zhanni
;
Wu, Lingyan
;
Duan, Yanan
;
Wang, Jiang
;
Zhou, Shengbin
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Adenosine 5 '-monophosphate-activated protein kinase
AMPK activators
Berberine
Tetrahydroberberine
T2DM
identificationofcompoundd2923asanovelantitumoragenttargetingcsf1r
期刊论文
actapharmacologicasinica, 2018, 卷号: 039, 期号: 011, 页码: 1768
作者:
Liu Yingqiang
;
Wang Yanan
;
Lu Xiaoyun
;
Tong Linjiang
;
Li Yan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
肿瘤组织
代理人
apoptosis
生长抑制率
复合
指向
鉴定
巨噬细胞
Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464
作者:
Zhou, Shengbin
;
Duan, Yanan
;
Wang, Jiang
;
Zhang, Jin
;
Sun, Haifeng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines
Mitochondrial respiration
AMPK indirect activators
db/db mice
Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 82, 期号: 10, 页码: 5263-5273
作者:
Xie, Yanan
;
Wu, Xiaowei
;
Li, Chunpu
;
Wang, Jiang
;
Li, Jian
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery
期刊论文
Chinese Journal of New Drugs and Clinical Remedies, 2014, 卷号: 33, 期号: 9, 页码: 683-688
作者:
Li Meiyun
;
Liu Jinfen
;
Zhao Yanan
;
Chen Xi
;
Gan Yong
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
tranexamic acid
nanostructures
administration, cutaneous
transdermal effect
nano - cream
In vitro study on gene transfection efficiency of hyaluronic acid modified core-shell liponanoparticles in human retinal pigment epithelium cells
期刊论文
Acta Pharmaceutica Sinica, 2014, 卷号: 49, 期号: 5, 页码: 711-717
作者:
Zhao Yanan
;
Gan Li
;
Wang Jing
;
Chen Xi
;
Jia Zheng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
hyaluronic acid
core-shell nanoparticle
ARPE-19
gene delivery system
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