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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Yang, Xiuyan;  Zhang, Xi;  Huang, Min;  Song, Kun;  Li, Xuefen 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532 作者:  Chen, Wen-hua;  Song, Shan-shan;  Qi, Ming-hui;  Huan, Xia-juan;  Wang, Ying-qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PARP-1 inhibitor  olaparib  breast cancer  BRCA-deficient tumors   Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531 作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Antitumor drug  BRCA1/2  PARP inhibitors  Molecular docking   Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials 期刊论文 CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56 作者:  Yuan, Bo;  Ye, Na;  Song, Shan-Shan;  Wang, Yu-Ting;  Song, Zilan 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 Homologous recombination repair defects  Olaparib  Growth inhibition  Patient-derived xenografts  Pharmacokinetics   Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168 作者:  He, Jin-Xue;  Wang, Meng;  Huan, Xia-Juan;  Chen, Chuan-Huizi;  Song, Shan-Shan 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 MPH  PARP inhibitor  homologous recombination  antitumor activity  synthetic lethality   SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1156-1171 作者:  Wei, Manman;  Zhang, Xi;  Wang, Xiang;  Song, Zilan;  Ding, Jian 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Chronic lymphocytic leukemia  PI3K delta  Structure-activity relationship  5-Alkynyl  Quinazolinone   discoveryofpotent24difluorolinkerpolyadpribosepolymerase1inhibitorswithenhancedwatersolubilityandinvivoanticancerefficacy 期刊论文 actapharmacologicasinica, 2017, 卷号: 38, 期号: 11, 页码: 1521 作者:  Chen Wenhua;  Song Shanshan;  Ql Minghui;  Huan Xiajuan;  Wang Yingqing 收藏  |  浏览/下载：5/0  |  提交时间：2020/07/01 PARP INHIBITORS  MEDICINAL CHEMISTRY  DRUG DISCOVERY  CANCER  THERAPY  DESIGN  FLUORINE  SUCCESS  PREDICT  METRICS  PARP-1 inhibitor  olaparib  breast cancer  BRCA-deficient tumors