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Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载:13/0  |  提交时间:2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. 期刊论文
The Journal of biological chemistry, 2014, 卷号: 289, 期号: 25, 页码: 17299-17311
作者:  Xu, Chao;  Liu, Ke;  Tempel, Wolfram;  Demetriades, Marina;  Aik, WeiShen
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/23
GmFLD, a soybean homolog of the autonomous pathway gene FLOWERING LOCUS D, promotes flowering in Arabidopsis thaliana 期刊论文
BMC Plant Biology, 2014, 卷号: 14, 期号: 1, 页码: 263
作者:  Hu, Qin;  Jin, Ye;  Shi, Huazhong;  Yang, Wannian*
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/23
A plant-specific histone H3 lysine 4 demethylase represses the floral transition in Arabidopsis 期刊论文
Plant Journal, 2010, 卷号: 62, 期号: 4, 页码: 663-673
作者:  Yang, Wannian;  Jiang, Danhua;  Jiang, Jiafu;  He, Yuehui*
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/23


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