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科研机构
华中师范大学 [4]
内容类型
期刊论文 [4]
发表日期
2015 [1]
2014 [2]
2010 [1]
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专题:华中师范大学
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Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:
Liu, Ke
;
Liu, Yanli
;
Lau, Johnathan L
;
Min, Jinrong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Histone demethylation
DNA methylation
Inhibitor
Chemical probe
Drug discovery
LSD
lysine-specific histone demethylase
HDAC
histone deacetylase
REST
REST corepressor
DNMT
DNA methyltransferase
MAO
monoamine oxidase
AML
acute myeloid leukemia
KDM
lysine-specific demethylase
MLL
mixed lineage leukemia
FAD
flavin adenine dinucleotide
PCPA
trans-2-phenylcyclopropylamine
2,4-PDCA
2, 4-pyridinedicarboxylic acid
PHD
plant homeobox domain
SCLC
small cell lung cancer
JHDMs
JmjC-domain-containing histone demethylases
NOG
N-oxalylglycine
IOX1
5-carboxy-8-hydroxyquinoline
MDS
myelodysplastic syndrome
2-OG, 2-oxoglutarate or
α-ketoglutarate
G9a
euchromatic histone-lysine N-methyltransferase 2
CoREST complex
restin corepressor complex
SAH
S-adenosyl-l-homocysteine
l
SWI complex
ATP dependent chromatin remodeling complexes
Pan-Histone Demethylase Inhibitor
the inhibitor can simultaneously inhibit both LSDs and JHDMs
LSC colony
leukemic stem cell colony
Pan JmjC domain-containing demethylase inhibitor
the inhibitor can simultaneously inhibit all the members of JHDMs
E2F1
E2F transcription factor 1
E2F2
E2F transcription factor 2
RCC
renal cell carcinoma
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
期刊论文
The Journal of biological chemistry, 2014, 卷号: 289, 期号: 25, 页码: 17299-17311
作者:
Xu, Chao
;
Liu, Ke
;
Tempel, Wolfram
;
Demetriades, Marina
;
Aik, WeiShen
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Crystal Structure
Dioxygenase
Isothermal Titration Calorimetry (ITC)
RNA Catalysis
RNA Methylation
Tricarboxylic Acid Cycle (TCA Cycle) (Krebs Cycle)
GmFLD, a soybean homolog of the autonomous pathway gene FLOWERING LOCUS D, promotes flowering in Arabidopsis thaliana
期刊论文
BMC Plant Biology, 2014, 卷号: 14, 期号: 1, 页码: 263
作者:
Hu, Qin
;
Jin, Ye
;
Shi, Huazhong
;
Yang, Wannian*
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Autonomous pathway
Deacetylation
Demethylation
FLOWERING LOCUS D
Flowering transition
GmFLD
Histone demethylase
Soybean
A plant-specific histone H3 lysine 4 demethylase represses the floral transition in Arabidopsis
期刊论文
Plant Journal, 2010, 卷号: 62, 期号: 4, 页码: 663-673
作者:
Yang, Wannian
;
Jiang, Danhua
;
Jiang, Jiafu
;
He, Yuehui*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
FT
Flowering
H3K4 demethylase
Histone demethylation
JmjC-domain protein
TSF
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