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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
发表日期
2019 [1]
2018 [1]
2017 [2]
2012 [1]
2011 [2]
2010 [6]
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Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 9, 页码: 2599-2608
作者:
Li Yingjun
;
Zhao Yue
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
1,3,4-thiadiazolamide
carbazole
benzimidazole
synthesis
PTP1B inhibitor
molecular docking
density functional theory (DFT) study
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 692-700
作者:
Du, Yongli
;
Zhang, Yanhui
;
Ling, Hao
;
Li, Qunyi
;
Shen, Jingkang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B inhibitors
N-(2,5-diethoxy-phenyl)-methane sulfonamide
Type 2 diabetes mellitus
PTP1B
Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1673-1682
作者:
Liu, Shi-en
;
Hu, Jun-chi
;
Zhang, Hao
;
Xu, Pan
;
Wan, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
phosphoglycerate mutase 1 (PGAM1)
human cancers
metabolic target
C-terminal region
conformational changes
molecular dynamics simulation
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:
Qu, Chunrong
;
Ding, Mingmin
;
Zhu, Yingmin
;
Lu, Yungang
;
Du, Juan
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  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 24, 页码: 7440-7443
作者:
Dai, Hou-ling
;
Gao, Li-xin
;
Yang, Ying
;
Li, Jing-ya
;
Cheng, Jia-gao
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Molecular docking
Inhibitors
Di-indolinone
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 13, 页码: 3892-3900
作者:
He, Xiao-Peng
;
Deng, Qiong
;
Gao, Li-Xin
;
Li, Cui
;
Zhang, Wei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Sugar template
Click chemistry
Amino acid
PTP inhibitor
MTT assay
Monosaccharide as a Central Scaffold Toward the Construction of Salicylate-Based Bidentate PTP1B Inhibitors via Click Chemistry
期刊论文
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 卷号: 32, 期号: 3, 页码: 1000-1006
作者:
Tang, Yan-Hui
;
Hu, Min
;
He, Xiao-Peng
;
Fahnbulleh, Sando
;
Li, Cui
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Monosaccharide
Structural preference
Click chemistry
Protein tyrosine phosphatase 1B (PTP1B) inhibitor
Triazole-linked Benzylated Glucosyl, Galactosyl, and Mannosyl Monomers and Dimers as Novel Sugar Scaffold-based PTP1B Inhibitors
期刊论文
CHEMISTRY LETTERS, 2010, 卷号: 39, 期号: 12, 页码: 1261-1263
作者:
Zhang, Yin Jie
;
He, Xiao-Peng
;
Li, Cui
;
Li, Zhen
;
Shi, De-Tai
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity
期刊论文
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2010, 卷号: 31, 期号: 11, 页码: 3359-3365
作者:
Yang, Jin-Wei
;
Li, Cui
;
He, Xiao-Peng
;
Zhao, Hong
;
Gao, Li-Xin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Click chemistry
Microwave irradiation
Carbohydrate-based drug discovery
PTP1B inhibitor
Docking simulation
Synthesis and LAR inhibition of 7-alkoxy analogues of illudalic acid
期刊论文
Yao xue xue bao = Acta pharmaceutica Sinica, 2010, 卷号: 45, 期号: 11, 页码: 1385-97
作者:
Ling, Qing
;
Zhou, Yue-Yang
;
Cai, Zheng-Liang
;
Zhang, Ya-Hui
;
Xiong, Bing
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/01/08
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