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上海药物研究所 [60]
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期刊论文 [192]
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2015 [202]
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Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity
期刊论文
CARBOHYDRATE RESEARCH, 2015, 卷号: 418, 页码: 44-49
作者:
Li, Q
;
Tan, WQ
;
Zhang, CL
;
Gu, GD
;
Guo, ZY
收藏
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浏览/下载:22/0
  |  
提交时间:2016/04/24
Chitosan derivatives
1,2,3-Triazole
Antifungal activity
Aliphatic alcohol
Chain length
FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90
期刊论文
NUCLEAR SCIENCE AND TECHNIQUES, 2015, 卷号: 26, 期号: 6
作者:
Li Jian
;
Shi Feng
;
Chen Dan-Qi
;
Cao Hui-Ling
;
Xiong Bing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Heat shock protein 90
N-terminal domain
Inhibitor
X-ray diffraction
Interactions
HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes
期刊论文
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015, 卷号: 55, 期号: 3, 页码: 197-207
作者:
Tan, Hayden Weng Siong
;
Sim, Arthur Yi Loong
;
Huang, Su Ling
;
Leng, Ying
;
Long, Yun Chau
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  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
histone deacetylase (HDAC)
Akt
insulin receptor substrate 1 (IRS1)
metabolism
exercise
myotubes
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12, 页码: 1528-1536
作者:
Gao, Zhi-wei
;
Zhu, Yun-ting
;
Yu, Ming-ming
;
Zan, Bin
;
Liu, Jia
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: Design, synthesis, and structure-activity relationship study
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 105, 页码: 39-56
作者:
Jiang, Xiaolong
;
Zhou, Ji
;
Ai, Jing
;
Song, Zilan
;
Peng, Xia
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/01/08
Benzo[b]carbazolones
ALK inhibitors
Anti-cancer
Anti-resistance
Non-small-cell lung cancer
Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 21, 页码: 8529-8541
作者:
Chen, Xinde
;
Xu, Wenwei
;
Wang, Kai
;
Mo, Mingguang
;
Zhang, Wei
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  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-ary1-6-aryl-aminopyridines as potent antibacterial agents against Helicobacter pylori (HP)
期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 45, 页码: 8628-8636
作者:
Huang, Jijun
;
Zhou, Jie
;
Song, Senchuan
;
Song, Huacan
;
Chen, Zhiyong
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  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
ZnCl2-catalyzed cyclization
2,6-Diamino-3,5-dicyano-4-aiylpyridines
Antibacterial activity
Helicobacter Pylori (HP)
Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation
期刊论文
Oncology Letters, 2015, 卷号: 10, 页码: 2856-2864
作者:
Yang, Lina
;
Liu, Yuanyuan
;
Sun, Chao
;
Yang, Xinrui
;
Yang, Zhen
收藏
  |  
浏览/下载:145/0
  |  
提交时间:2018/05/31
ATM
ATR
carbon ion
DNA-PKcs
radiosensitivity
Triazolyl-acylhydrazone derivatives as novel inhibitors for copper corrosion in chloride solutions
期刊论文
CORROSION SCIENCE, 2015, 卷号: 100, 期号: 2015, 页码: 341-352
作者:
Tian, Huiwen
;
Cheng, Y. Frank
;
Li, Weihua
;
Hou, Baorong
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2015/12/15
Copper
EIS
Polarization
Effects of fermentation by-products and inhibitors on pervaporative recovery of biofuels from fermentation broths with novel silane modified silicalite-1/PDMS/PAN thin film composite membrane
期刊论文
CHEMICAL ENGINEERING JOURNAL, 2015, 卷号: 279, 期号: NOV, 页码: 547-554
作者:
Yi, Shouliang
;
Qi, Benkun
;
Su, Yi
;
Wan, Yinhua
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2015/10/08
Vinyltriethoxysilane
Pervaporation
Fermentation inhibitors
By-products
Bioethanol
Lignocellulosic hydrolysates
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