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科研机构
北京大学 [5]
南华大学 [3]
兰州大学 [2]
上海药物研究所 [2]
安徽大学 [2]
厦门大学 [1]
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期刊论文 [21]
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2019 [1]
2018 [3]
2017 [3]
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Oncology [2]
chemistry [2]
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The kinase domain of CK1 delta can be phosphorylated by Chk1
期刊论文
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2019, 卷号: 83, 期号: 9, 页码: 1663-1675
作者:
Boehm, Thomas
;
Meng, Zhigang
;
Haas, Philipp
;
Henne-Bruns, Doris
;
Rachidi, Najma
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/11
Casein kinase 1
Checkpoint kinase 1
site-specific phosphorylation
enzyme kinetics
phosphopeptide analysis
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2018, 卷号: 76, 页码: 53-60
作者:
Li, Yaping
;
Peng, Jiale
;
Zhou, Yeheng
;
Li, Penghua
;
Li, Yingying
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2018/11/12
Checkpoint kinase 1 inhibitor
Virtual screening
Pharmacophore modeling
Molecular docking
Molecular dynamics simulations
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1
期刊论文
Computational Biology and Chemistry, 2018
作者:
Yaping Li
;
Jiale Peng
;
Yeheng Zhou
;
Penghua Li
;
Yingying Li
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/28
Checkpoint
kinase
1
inhibitor
virtual
screening
pharmacophore
modeling
molecular
docking
molecular
dynamics
simulations
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53-deficient pancreatic cancer cells
期刊论文
MOLECULAR MEDICINE REPORTS, 2018, 卷号: Vol.17 No.1, 页码: 117-124
作者:
Jing, W
;
Song, N
;
Liu, YP
;
Qu, XJ
;
Hou, KZ
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/26
cell
cycle
checkpoint
kinase
1
DNA
methyltransferase
3a
pancreatic
ductal
adenocarcinoma
chemosensitivity
The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4
作者:
Zhou, Zhi-rui
;
Yang, Zhao-zhi
;
Wang, Shao-jia
;
Zhang, Li
;
Luo, Ju-rui
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
human triple-negative breast cancer
checkpoint kinase 1
MK-8776
radiosensitivity
autophagy
xenograft tumors
The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation
期刊论文
CELLULAR AND MOLECULAR LIFE SCIENCES, 2017
Liu, Junjun
;
Zhang, Chuanmao
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2017/12/03
Polo-like kinase 1
Mitosis
Usp16
Kinetochore
Cullin 3
E3 ligase
POLO-LIKE KINASES
KINETOCHORE-MICROTUBULE DYNAMICS
SPINDLE ASSEMBLY CHECKPOINT
PROPER CHROMOSOME SEGREGATION
CELL-DIVISION
BOX DOMAIN
PROTEIN
PHOSPHORYLATION
STABILITY
COMPLEX
Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration
期刊论文
DEVELOPMENTAL CELL, 2017
Yi, Cong
;
Tong, Jingjing
;
Lu, Puzhong
;
Wang, Yizheng
;
Zhang, Jinxie
;
Sun, Chen
;
Yuan, Kangning
;
Xue, Renyu
;
Zou, Bing
;
Li, Nianzhong
;
Xiao, Shuhua
;
Dai, Chong
;
Huang, Yuwei
;
Xu, Liling
;
Li, Lin
;
Chen, She
;
Miao, Di
;
Deng, Haiteng
;
Li, Hongliang
;
Yu, Li
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
SACCHAROMYCES-CEREVISIAE
PROTEIN-KINASE
MONITORING AUTOPHAGY
SIGNALING PATHWAYS
DNA-REPLICATION
YEAST
CHECKPOINT
PHOSPHORYLATION
STRESS
SNF1
Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis
期刊论文
JOURNAL OF CELL BIOLOGY, 2015
Zhuo, Xiaolong
;
Guo, Xiao
;
Zhang, Xiaoyan
;
Jing, Guihua
;
Wang, Yao
;
Chen, Qiang
;
Jiang, Qing
;
Liu, Junjun
;
Zhang, Chuanmao
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2017/12/03
SPINDLE ASSEMBLY CHECKPOINT
CELL-CYCLE PROGRESSION
POLO-LIKE KINASES
MICROTUBULE ATTACHMENTS
PLK1-PBIP1 INTERACTION
PHOSPHORYLATION
POLO-LIKE-KINASE-1
DYNAMICS
PROTEIN
BUBR1
A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphase
期刊论文
BMC CELL BIOLOGY, BMC CELL BIOLOGY, 2015, 卷号: Vol.16
作者:
Ma,Runlin Z.
;
Zhang,Xiaojuan
;
Wang,Xue
;
Cao,Cheng
;
Bai,Yuanyuan
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/04/24
SPINDLE ASSEMBLY CHECKPOINT
AURORA-B
CENTROSOME DUPLICATION
KINETOCHORE LOCALIZATION
PROTEIN-KINASE
HELA-CELLS
TPR DOMAIN
PHOSPHORYLATION
TTK/HMPS1
CRM1
Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy.
期刊论文
Biochemical and Biophysical Research Communications, 2014, 卷号: Vol.450 No.4, 页码: 1690-1695
作者:
Zhang,Xiaojuan
;
Song,Ting
;
Wei,Congwen
;
Bai,Yuanyuan
;
Guan,Kai
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/22
MITOTIC CHECKPOINT
KINASE
BUBR1
SLIPPAGE
PHOSPHORYLATION
KINETOCHORES
INHIBITION
MITOSIS
ARREST
CDC20
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