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Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 92
作者:
Yin, Yong
;
Zhou, Yang
;
Sha, Shao
;
Wu, Xun
;
Wang, She-Feng
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/18
EMBRYONIC LETHALITY
PATHWAY
KINASE
PI3K
DISCOVERY
3-KINASES
SUBUNIT
GROWTH
POTENT
TARGET
Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methylbiphenyl Moiety
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2019, 卷号: 35, 期号: 3, 页码: 410-417
作者:
Ma Junjie
;
Huang Kun
;
Ni Xin
;
Chen Roufen
;
Xu Boxuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2021/02/02
GROWTH
POTENT
Coumarin
2-Methylbiphenyl
Anticancer activity
PD-1/PD-L1 inhibitory activity
Molecular docking
chemicalinterventiononstaphylococcusaureusvirulence
期刊论文
chinesejournalofchemistry, 2019, 卷号: 37, 期号: 2, 页码: 183
作者:
Zhou Linlin
;
Yang Caiguang
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  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
BACTERIAL VIRULENCE
ALPHA-TOXIN
POTENT INHIBITORS
SURFACE-PROTEINS
GENE-EXPRESSION
CLPP PROTEASE
SORTASE
BIOSYNTHESIS
DISCOVERY
STAPHYLOXANTHIN
c11anovelfibroblastgrowthfactorreceptor1fgfr1inhibitorsuppressesbreastcancermetastasisandangiogenesis
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 6, 页码: 823
作者:
Chen Zhuo
;
Tong Linjiang
;
Tang Baiyou
;
Liu Hongyan
;
Wang Xin
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  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
SELECTIVE INHIBITOR
THERAPEUTIC TARGET
DISCOVERY
ACTIVATION
EXPRESSION
PATHWAY
POTENT
C11
FGFR1 inhibitor
antitumor
breast cancer
metastasis
angiogenesis
GOLPH2-regulated oncolytic adenovirus, GD55, exerts strong killing effect on human prostate cancer stem-like cells in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 3, 页码: 405-414
作者:
Ying, Chang
;
Xiao, Bo-duan
;
Qin, Yun
;
Wang, Bin-rong
;
Liu, Xin-yuan
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  |  
浏览/下载:45/0
  |  
提交时间:2019/04/28
Potent Antitumor-activity
Colorectal-cancer
Gene
Identification
Heterogeneity
Plasticity
Resistance
Xenograft
Promoter
Efficacy
A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging
期刊论文
CHEMICAL COMMUNICATIONS, 2018, 卷号: 54, 期号: 63, 页码: 8773-8776
作者:
Sun, Shan
;
Wu, Aiguo
;
Xing, Jie
;
Gong, Qiuyu
;
Zhang, Renshuai
收藏
  |  
浏览/下载:218/0
  |  
提交时间:2018/12/04
Fibroblast Activation Protein
Fluorescence Probes
Inhibitors
Cells
Mechanisms
Enzyme
Potent
Vitro
Dpp4
Vivo
Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3634-3638
作者:
Luo, Yin
;
Zhou, Yang
;
Song, Yanhua
;
Chen, Guo
;
Wang, Yu-Xiang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/18
BIOLOGICAL EVALUATION
BINDING
DISCOVERY
POTENT
SITE
Whole Exome Sequencing Identified a Novel IGFBP6 Variant in a Disc Degeneration Pedigree
期刊论文
GENETIC TESTING AND MOLECULAR BIOMARKERS, 2017, 卷号: 21, 页码: 580-585
作者:
Sun Fu
;
Wang Lei
;
Dai Lanlan
;
Yuan Qi-ling
;
Liu Liang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/11/26
single nucleotide polymorphism variant
potent gene
exome sequencing
disc degeneration
Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino) benzamides leading to a series of potent hedgehog signaling pathway inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 页码: 3259-3263
作者:
Xin, Minhang
;
Zhang, Liandi
;
Wen, Jun
;
Shen, Han
;
Zhao, Xinge
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/11/26
Most potent
Hedgehog signaling pathway inhibitors
4-(2-Pyrimidinylamino) benzamide scaffold
Fluorine
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