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Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus
期刊论文
MOLECULAR MICROBIOLOGY, 2020, 页码: 20
作者:
Yang, Nana
;
Cao, Qiao
;
Hu, Shuyang
;
Xu, Chenchen
;
Fan, Ke
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  |  
浏览/下载:130/0
  |  
提交时间:2020/07/01
ClpXP
microbial interspecies interactions
proteolysis
Pseudomonas aeruginosa
quorum sensing
Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14
作者:
Zhang, Xin
;
Xu, Fang
;
Tong, Linjiang
;
Zhang, Tao
;
Xie, Hua
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  |  
浏览/下载:80/0
  |  
提交时间:2020/07/01
Epidermal growth factor receptor (EGFR)
Resistance
Proteolysis targeting chimera (PROTAC)
Protein degradation
Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock
期刊论文
MOLECULAR PLANT, 2020, 卷号: 13, 期号: 3, 页码: 446-458
作者:
Wang, Yan
;
He, Yuqing
;
Su, Chen
;
Zentella, Rodolfo
;
Sun, Tai-ping
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  |  
浏览/下载:15/0
  |  
提交时间:2022/03/01
circadian clock
O-fucosyltransferase
SPY
proteolysis
PRR5
Vif-CBF beta interaction is essential for Vif-induced cell cycle arrest
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 511, 期号: 4
作者:
Sun, Tianmeng
;
Du, Juan
;
Rui, Yajuan
;
Zheng, Wenwen
;
Li, Peng
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  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
CBF beta
Vif
Cell cycle regulation
Proteasome-mediated proteolysis
Vif-CBFβ interaction is essential for Vif-induced cell cycle arrest.
期刊论文
Biochemical and biophysical research communications, 2019
作者:
Juan Du
;
Yajuan Rui
;
Wenwen Zheng
;
Peng Li
;
Jian Kang
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/13
CBFβ
Cell cycle regulation
Proteasome-mediated proteolysis
Vif
Triple deletion of clpC, porB, and mepA enhances production of small ubiquitin-like modifier-N-terminal pro-brain natriuretic peptide in Corynebacterium glutamicum.
期刊论文
Journal of Industrial Microbiology & Biotechnology, 2019, 卷号: Vol.46 No.1, 页码: 67-79
作者:
Peng, Feng
;
Liu, Xiuxia
;
Wang, Xinyue
;
Chen, Jing
;
Liu, Meng
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  |  
浏览/下载:20/0
  |  
提交时间:2019/12/13
GENOME
editing
*CRISPRS
(Genetics)
*CORYNEBACTERIUM
glutamicum
*PROTEOLYSIS
*RECOMBINANT
proteins
*CORYNEBACTERIUM
Comparative study of the insoluble and soluble Ulp1 protease constructs as Carrier free and dependent protein immobilizates.
期刊论文
Journal of Bioscience & Bioengineering, 2019, 卷号: Vol.127 No.1, 页码: 23-29
作者:
Jiang, Li
;
Xiao, Wenjun
;
Zhou, Xuan
;
Wang, Weiyu
;
Fan, Jun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/17
PROTEASE
inhibitors
*ESCHERICHIA
coli
proteins
*MOLECULAR
self-assembly
*PROTEOLYSIS
*THIOFLAVINS
Proteolysis-targeting chimeras for targeting protein for degradation
期刊论文
2019, 卷号: 11, 期号: 7, 页码: 723-742
作者:
Qi, Jianguo
;
Zhang, Gang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
E3 ligase
protein degradation
proteolysis-targeting chimeras
Design and Synthesis of Novel Bispecific Molecules for Inducing BRD4 Protein Degradation
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2018, 卷号: 34, 期号: 1
作者:
Song Yuming
;
Wang Yue
;
Gao Yang
;
Yu Shanshan
;
Zhao Qianqian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Proteolysis targeting chimera(PROTAC)
Bromodomain-containing protein 4(BRD4) degrader
Bromodomain containing protein 4(BRD4) inhibitor
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